2,2-Difluoro-1,3-diketones as gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzylisatins

Jinlong Qian; Wenbin Yi; Xin Huang; Jerry P. Jasinski; Wei Zhang

doi:10.1002/adsc.201600392

2,2-Difluoro-1,3-diketones as gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzylisatins

Jinlong Qian
, Wenbin Yi
, Xin Huang
, Jerry P. Jasinski
, Wei Zhang

Chemistry

Nanjing University of Science and Technology
University of Massachusetts Boston
Keene State College

Research output: Contribution to journal › Article › peer-review

Abstract

2,2-Difluoro-1,3-diketones are introduced as gem-difluoroenolate precursors for the first example of an organocatalytic asymmetric aldol addition with N-benzylisatins to form 3-difluoroalkyl-3-hydroxyoxindoles. (Figure presented.).

Original language	English
Pages (from-to)	2811-2816
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	358
Issue number	17
DOIs	https://doi.org/10.1002/adsc.201600392
State	Published - Sep 1 2016

ASJC Scopus Subject Areas

Catalysis
Organic Chemistry

Keywords

2,2-difluoro-1,3-diketones
difluoroalkylation
difluoroenolates
enantioselectivity
organocatalysis

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10.1002/adsc.201600392

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title = "2,2-Difluoro-1,3-diketones as gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzylisatins",

abstract = "2,2-Difluoro-1,3-diketones are introduced as gem-difluoroenolate precursors for the first example of an organocatalytic asymmetric aldol addition with N-benzylisatins to form 3-difluoroalkyl-3-hydroxyoxindoles. (Figure presented.).",

keywords = "2,2-difluoro-1,3-diketones, difluoroalkylation, difluoroenolates, enantioselectivity, organocatalysis",

author = "Jinlong Qian and Wenbin Yi and Xin Huang and Jasinski, \{Jerry P.\} and Wei Zhang",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

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T1 - 2,2-Difluoro-1,3-diketones as gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzylisatins

AU - Qian, Jinlong

AU - Yi, Wenbin

AU - Huang, Xin

AU - Jasinski, Jerry P.

AU - Zhang, Wei

PY - 2016/9/1

Y1 - 2016/9/1

N2 - 2,2-Difluoro-1,3-diketones are introduced as gem-difluoroenolate precursors for the first example of an organocatalytic asymmetric aldol addition with N-benzylisatins to form 3-difluoroalkyl-3-hydroxyoxindoles. (Figure presented.).

AB - 2,2-Difluoro-1,3-diketones are introduced as gem-difluoroenolate precursors for the first example of an organocatalytic asymmetric aldol addition with N-benzylisatins to form 3-difluoroalkyl-3-hydroxyoxindoles. (Figure presented.).

KW - 2,2-difluoro-1,3-diketones

KW - difluoroalkylation

KW - difluoroenolates

KW - enantioselectivity

KW - organocatalysis

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UR - https://www.scopus.com/pages/publications/84986191355#tab=citedBy

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SP - 2811

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JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 17

ER -

2,2-Difluoro-1,3-diketones as gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzylisatins

Abstract

ASJC Scopus Subject Areas

Keywords

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