A novel bromodomain inhibitor reverses HIV-1 latency through specific binding with BRD4 to promote Tat and P-TEFb association

  • Huachao Huang
  • , Shuai Liu
  • , Maxime Jean
  • , Sydney Simpson
  • , He Huang
  • , Mark Merkley
  • , Tsuyoshi Hayashi
  • , Weili Kong
  • , Irene Rodríguez-Sánchez
  • , Xiaofeng Zhang
  • , Hailemichael O. Yosief
  • , Hongyu Miao
  • , Jianwen Que
  • , James J. Kobie
  • , James Bradner
  • , Netty G. Santoso
  • , Wei Zhang
  • , Jian Zhu

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number1035
JournalFrontiers in Microbiology
Volume8
Issue numberJUN
DOIs
StatePublished - Jun 7 2017

ASJC Scopus Subject Areas

  • Microbiology
  • Microbiology (medical)

Keywords

  • BETi
  • BRD4
  • HIV-1
  • JQ1
  • Latency
  • LRA
  • Reactivation
  • UMB-136

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