Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

Fen Ma; Sen Chen; Luigi Cecchi; Betul Ersoy-Fazlioglu; Joshua W. Russo; Seiji Arai; Seifeldin Awad; Carla Calagua; Fang Xie; Larysa Poluben; Olga Voznesensky; Anson T. Ku; Fatima Karzai; Changmeng Cai; David J. Einstein; Huihui Ye; Xin Yuan; Alex Toker; Mary Ellen Taplin; Adam G. Sowalsky; Steven P. Balk

doi:10.1172/JCI192368

Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

Fen Ma
, Sen Chen
, Luigi Cecchi
, Betul Ersoy-Fazlioglu
, Joshua W. Russo
, Seiji Arai
, Seifeldin Awad
, Carla Calagua
, Fang Xie
, Larysa Poluben
, Olga Voznesensky
, Anson T. Ku
, Fatima Karzai
, Changmeng Cai
, David J. Einstein
, Huihui Ye
, Xin Yuan
, Alex Toker
, Mary Ellen Taplin
, Adam G. Sowalsky

Steven P. Balk

Biology

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e192368
Pages (from-to)	1-13
Number of pages	13
Journal	Journal of Clinical Investigation
Volume	135
Issue number	23
DOIs	https://doi.org/10.1172/JCI192368
State	Published - Dec 2025

ASJC Scopus Subject Areas

General Medicine

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10.1172/JCI192368

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Ma, F., Chen, S., Cecchi, L., Ersoy-Fazlioglu, B., Russo, J. W., Arai, S., Awad, S., Calagua, C., Xie, F., Poluben, L., Voznesensky, O., Ku, A. T., Karzai, F., Cai, C., Einstein, D. J., Ye, H., Yuan, X., Toker, A., Taplin, M. E., ... Balk, S. P. (2025). Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion. Journal of Clinical Investigation, 135(23), 1-13. Article e192368. https://doi.org/10.1172/JCI192368

Ma, F, Chen, S, Cecchi, L, Ersoy-Fazlioglu, B, Russo, JW, Arai, S, Awad, S, Calagua, C, Xie, F, Poluben, L, Voznesensky, O, Ku, AT, Karzai, F, Cai, C, Einstein, DJ, Ye, H, Yuan, X, Toker, A, Taplin, ME, Sowalsky, AG & Balk, SP 2025, 'Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion', Journal of Clinical Investigation, vol. 135, no. 23, e192368, pp. 1-13. https://doi.org/10.1172/JCI192368

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title = "Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion",

author = "Fen Ma and Sen Chen and Luigi Cecchi and Betul Ersoy-Fazlioglu and Russo, \{Joshua W.\} and Seiji Arai and Seifeldin Awad and Carla Calagua and Fang Xie and Larysa Poluben and Olga Voznesensky and Ku, \{Anson T.\} and Fatima Karzai and Changmeng Cai and Einstein, \{David J.\} and Huihui Ye and Xin Yuan and Alex Toker and Taplin, \{Mary Ellen\} and Sowalsky, \{Adam G.\} and Balk, \{Steven P.\}",

note = "Publisher Copyright: {\textcopyright} 2025, Ma et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.",

year = "2025",

month = dec,

doi = "10.1172/JCI192368",

language = "English",

volume = "135",

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AU - Ma, Fen

AU - Chen, Sen

AU - Cecchi, Luigi

AU - Ersoy-Fazlioglu, Betul

AU - Russo, Joshua W.

AU - Arai, Seiji

AU - Awad, Seifeldin

AU - Calagua, Carla

AU - Xie, Fang

AU - Poluben, Larysa

AU - Voznesensky, Olga

AU - Ku, Anson T.

AU - Karzai, Fatima

AU - Cai, Changmeng

AU - Einstein, David J.

AU - Ye, Huihui

AU - Yuan, Xin

AU - Toker, Alex

AU - Taplin, Mary Ellen

AU - Sowalsky, Adam G.

AU - Balk, Steven P.

PY - 2025/12

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UR - https://www.scopus.com/pages/publications/105023452552#tab=citedBy

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AN - SCOPUS:105023452552

SN - 0021-9738

VL - 135

SP - 1

EP - 13

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 23

M1 - e192368

ER -

Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

ASJC Scopus Subject Areas

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