TY - GEN
T1 - Biomolecular activity switch
T2 - 2008 ASME International Mechanical Engineering Congress and Exposition, IMECE 2008
AU - Alper, Joshua
AU - Hamad-Schifferli, Kimberly
PY - 2009
Y1 - 2009
N2 - With an increased effort within the engineering community to design molecular machines, it has become clear that a specific, external control method is required. Here we propose a simple mechanism for a molecular switch involving conjugating a molecule within the machinery to a gold nanorod. Then actuate that machinery's active state by affecting a change in the conjugated molecule. We demonstrate the feasibility of the method using a fluorescent probe, and we report on progress we have made toward demonstrating it with a protein.
AB - With an increased effort within the engineering community to design molecular machines, it has become clear that a specific, external control method is required. Here we propose a simple mechanism for a molecular switch involving conjugating a molecule within the machinery to a gold nanorod. Then actuate that machinery's active state by affecting a change in the conjugated molecule. We demonstrate the feasibility of the method using a fluorescent probe, and we report on progress we have made toward demonstrating it with a protein.
UR - https://www.scopus.com/pages/publications/70049109030
UR - https://www.scopus.com/pages/publications/70049109030#tab=citedBy
U2 - 10.1115/IMECE2008-68104
DO - 10.1115/IMECE2008-68104
M3 - Conference contribution
AN - SCOPUS:70049109030
SN - 9780791848630
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings
SP - 255
EP - 257
BT - Biomedical and Biotechnology Engineering
PB - American Society of Mechanical Engineers (ASME)
Y2 - 31 October 2008 through 6 November 2008
ER -