BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability

Kathy Situ; Haohui Duan; Stephen K. Godin; Joshua Yang; Gabrielle Q. McCloskey; Basim Naeem; Margaret K. Gillis; Muhammad H. Zeb; Silvi Salhotra; Pratha Rawal; Nisha Patel; Salome K. Mouliere; Jie Chen; Angéla Békési; Hajnalka L. Pálinkás; Subramanian Venkatesan; Abby M. Green; Nicolai J. Birkbak; Beáta G. Vértessy; Charles Swanton; Shailja Pathania

doi:10.1038/s41467-025-64578-6

BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability

Kathy Situ
, Haohui Duan
, Stephen K. Godin
, Joshua Yang
, Gabrielle Q. McCloskey
, Basim Naeem
, Margaret K. Gillis
, Muhammad H. Zeb
, Silvi Salhotra
, Pratha Rawal
, Nisha Patel
, Salome K. Mouliere
, Jie Chen
, Angéla Békési
, Hajnalka L. Pálinkás
, Subramanian Venkatesan
, Abby M. Green
, Nicolai J. Birkbak
, Beáta G. Vértessy
, Charles Swanton

Shailja Pathania

Biology

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	9544
Journal	Nature Communications
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/s41467-025-64578-6
State	Published - Dec 2025

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General
General Physics and Astronomy

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10.1038/s41467-025-64578-6

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Situ, K., Duan, H., Godin, S. K., Yang, J., McCloskey, G. Q., Naeem, B., Gillis, M. K., Zeb, M. H., Salhotra, S., Rawal, P., Patel, N., Mouliere, S. K., Chen, J., Békési, A., Pálinkás, H. L., Venkatesan, S., Green, A. M., Birkbak, N. J., Vértessy, B. G., ... Pathania, S. (2025). BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability. Nature Communications, 16(1), Article 9544. https://doi.org/10.1038/s41467-025-64578-6

Situ, K, Duan, H, Godin, SK, Yang, J, McCloskey, GQ, Naeem, B, Gillis, MK, Zeb, MH, Salhotra, S, Rawal, P, Patel, N, Mouliere, SK, Chen, J, Békési, A, Pálinkás, HL, Venkatesan, S, Green, AM, Birkbak, NJ, Vértessy, BG, Swanton, C & Pathania, S 2025, 'BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability', Nature Communications, vol. 16, no. 1, 9544. https://doi.org/10.1038/s41467-025-64578-6

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AU - Situ, Kathy

AU - Duan, Haohui

AU - Godin, Stephen K.

AU - Yang, Joshua

AU - McCloskey, Gabrielle Q.

AU - Naeem, Basim

AU - Gillis, Margaret K.

AU - Zeb, Muhammad H.

AU - Salhotra, Silvi

AU - Rawal, Pratha

AU - Patel, Nisha

AU - Mouliere, Salome K.

AU - Chen, Jie

AU - Békési, Angéla

AU - Pálinkás, Hajnalka L.

AU - Venkatesan, Subramanian

AU - Green, Abby M.

AU - Birkbak, Nicolai J.

AU - Vértessy, Beáta G.

AU - Swanton, Charles

AU - Pathania, Shailja

PY - 2025/12

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SN - 2041-1723

VL - 16

JO - Nature Communications

JF - Nature Communications

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BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability

ASJC Scopus Subject Areas

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