Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp3)-P Bond Formation

Cheng Kun Li; Ze Kun Tao; Adedamola Shoberu; Wei Zhang; Jian Ping Zou

doi:10.1021/acs.orglett.2c02454

Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp³)-P Bond Formation

Cheng Kun Li
, Ze Kun Tao
, Adedamola Shoberu
, Wei Zhang
, Jian Ping Zou

Chemistry

Soochow University

Research output: Contribution to journal › Article › peer-review

Abstract

A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H-P(O) compounds.

Original language	English
Pages (from-to)	6083-6087
Number of pages	5
Journal	Organic Letters
Volume	24
Issue number	32
DOIs	https://doi.org/10.1021/acs.orglett.2c02454
State	Published - Aug 19 2022

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.2c02454

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abstract = "A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H-P(O) compounds.",

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AU - Li, Cheng Kun

AU - Tao, Ze Kun

AU - Shoberu, Adedamola

AU - Zhang, Wei

AU - Zou, Jian Ping

PY - 2022/8/19

Y1 - 2022/8/19

N2 - A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H-P(O) compounds.

AB - A CuI-catalyzed cross-coupling of alkyl- and phosphorus-centered radicals for C(sp3)-P bond formation is introduced. Diacyl peroxides, generated in situ from aliphatic acids and H2O2, serve as a source for alkyl radicals and also an initiator for the generation of phosphorus radicals from H-P(O) compounds.

UR - https://www.scopus.com/pages/publications/85136555555

UR - https://www.scopus.com/pages/publications/85136555555#tab=citedBy

U2 - 10.1021/acs.orglett.2c02454

DO - 10.1021/acs.orglett.2c02454

M3 - Article

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AN - SCOPUS:85136555555

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JO - Organic Letters

JF - Organic Letters

IS - 32

ER -

Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp³)-P Bond Formation

Abstract

ASJC Scopus Subject Areas

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