Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones

Alex Muthengi; Jon Erickson; Rachel E. Muriph; Wei Zhang

doi:10.1021/acs.joc.9b00448

Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones

Alex Muthengi
, Jon Erickson
, Rachel E. Muriph
, Wei Zhang

Chemistry

University of Massachusetts Boston

Research output: Contribution to journal › Article › peer-review

Abstract

A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI-catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of fused-tetrahydrobenzodiazepin-3-ones.

Original language	English
Pages (from-to)	5927-5935
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	84
Issue number	9
DOIs	https://doi.org/10.1021/acs.joc.9b00448
State	Published - May 3 2019

ASJC Scopus Subject Areas

Organic Chemistry

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10.1021/acs.joc.9b00448

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title = "Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones",

abstract = "A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI-catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of fused-tetrahydrobenzodiazepin-3-ones.",

author = "Alex Muthengi and Jon Erickson and Muriph, \{Rachel E.\} and Wei Zhang",

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AU - Zhang, Wei

PY - 2019/5/3

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AB - A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI-catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of fused-tetrahydrobenzodiazepin-3-ones.

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Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones

Abstract

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