Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors

Alex Muthengi; Virangika K. Wimalasena; Hailemichael O. Yosief; Melissa J. Bikowitz; Logan H. Sigua; Tingjian Wang; Deyao Li; Zied Gaieb; Gagan Dhawan; Shuai Liu; Jon Erickson; Rommie E. Amaro; Ernst Schönbrunn; Jun Qi; Wei Zhang

doi:10.1021/acs.jmedchem.0c02232

Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors

Alex Muthengi
, Virangika K. Wimalasena
, Hailemichael O. Yosief
, Melissa J. Bikowitz
, Logan H. Sigua
, Tingjian Wang
, Deyao Li
, Zied Gaieb
, Gagan Dhawan
, Shuai Liu
, Jon Erickson
, Rommie E. Amaro
, Ernst Schönbrunn
, Jun Qi
, Wei Zhang

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	5787-5801
Number of pages	15
Journal	Journal of Medicinal Chemistry
Volume	64
Issue number	9
DOIs	https://doi.org/10.1021/acs.jmedchem.0c02232
State	Published - May 13 2021

ASJC Scopus Subject Areas

Molecular Medicine
Drug Discovery

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10.1021/acs.jmedchem.0c02232

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Muthengi, A., Wimalasena, V. K., Yosief, H. O., Bikowitz, M. J., Sigua, L. H., Wang, T., Li, D., Gaieb, Z., Dhawan, G., Liu, S., Erickson, J., Amaro, R. E., Schönbrunn, E., Qi, J., & Zhang, W. (2021). Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors. Journal of Medicinal Chemistry, 64(9), 5787-5801. https://doi.org/10.1021/acs.jmedchem.0c02232

Muthengi, A, Wimalasena, VK, Yosief, HO, Bikowitz, MJ, Sigua, LH, Wang, T, Li, D, Gaieb, Z, Dhawan, G, Liu, S, Erickson, J, Amaro, RE, Schönbrunn, E, Qi, J & Zhang, W 2021, 'Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors', Journal of Medicinal Chemistry, vol. 64, no. 9, pp. 5787-5801. https://doi.org/10.1021/acs.jmedchem.0c02232

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title = "Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors",

author = "Alex Muthengi and Wimalasena, \{Virangika K.\} and Yosief, \{Hailemichael O.\} and Bikowitz, \{Melissa J.\} and Sigua, \{Logan H.\} and Tingjian Wang and Deyao Li and Zied Gaieb and Gagan Dhawan and Shuai Liu and Jon Erickson and Amaro, \{Rommie E.\} and Ernst Sch{\"o}nbrunn and Jun Qi and Wei Zhang",

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doi = "10.1021/acs.jmedchem.0c02232",

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volume = "64",

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AU - Muthengi, Alex

AU - Wimalasena, Virangika K.

AU - Yosief, Hailemichael O.

AU - Bikowitz, Melissa J.

AU - Sigua, Logan H.

AU - Wang, Tingjian

AU - Li, Deyao

AU - Gaieb, Zied

AU - Dhawan, Gagan

AU - Liu, Shuai

AU - Erickson, Jon

AU - Amaro, Rommie E.

AU - Schönbrunn, Ernst

AU - Qi, Jun

AU - Zhang, Wei

PY - 2021/5/13

Y1 - 2021/5/13

UR - https://www.scopus.com/pages/publications/85105101612

UR - https://www.scopus.com/pages/publications/85105101612#tab=citedBy

U2 - 10.1021/acs.jmedchem.0c02232

DO - 10.1021/acs.jmedchem.0c02232

M3 - Article

C2 - 33872011

AN - SCOPUS:85105101612

SN - 0022-2623

VL - 64

SP - 5787

EP - 5801

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 9

ER -

Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors

ASJC Scopus Subject Areas

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