Discovery of a small molecule TLR3 agonist adjuvant

Branden Lee; Danica Dong; Etsuro Nanishi; John Mark Awad; Kimia Z. Abedi; Yoshine Saito; Francesco Borriello; Soumik Barman; Byron Brook; Aisling Kelly; Manisha Menon; Constance Marques-Mourlet; Maansi V. Gupta; Ida Lister; Chiwoo Oh; Kevin Lyskawa; Morgan Goetz; Kristina Walker; Wing Ki Cheng; Spencer E. Brightman; Pankaj Sharma; Timothy R. O’Meara; Katherine Chew; Daniel Vieira; Kevin Ryff; Cali Sweitzer; Sanya Thomas; Simon D. van Haren; Matthew Pettengill; Hyuk Soo Seo; Sirano Dhe-Paganon; Wei Zhang; Ofer Levy; David J. Dowling

doi:10.1038/s41467-025-66878-3

Discovery of a small molecule TLR3 agonist adjuvant

Branden Lee
, Danica Dong
, Etsuro Nanishi
, John Mark Awad
, Kimia Z. Abedi
, Yoshine Saito
, Francesco Borriello
, Soumik Barman
, Byron Brook
, Aisling Kelly
, Manisha Menon
, Constance Marques-Mourlet
, Maansi V. Gupta
, Ida Lister
, Chiwoo Oh
, Kevin Lyskawa
, Morgan Goetz
, Kristina Walker
, Wing Ki Cheng
, Spencer E. Brightman

Pankaj Sharma, Timothy R. O’Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon D. van Haren, Matthew Pettengill, Hyuk Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David J. Dowling

Chemistry

Boston Children's Hospital
Harvard University
University of Massachusetts Boston
Generate Biomedicines
Thomas Jefferson University
Dana-Farber Cancer Institute
Broad Institute

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	364
Journal	Nature Communications
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/s41467-025-66878-3
State	Published - Dec 2026

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General
General Physics and Astronomy

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Lee, B., Dong, D., Nanishi, E., Awad, J. M., Abedi, K. Z., Saito, Y., Borriello, F., Barman, S., Brook, B., Kelly, A., Menon, M., Marques-Mourlet, C., Gupta, M. V., Lister, I., Oh, C., Lyskawa, K., Goetz, M., Walker, K., Cheng, W. K., ... Dowling, D. J. (2026). Discovery of a small molecule TLR3 agonist adjuvant. Nature Communications, 17(1), Article 364. https://doi.org/10.1038/s41467-025-66878-3

Lee, B, Dong, D, Nanishi, E, Awad, JM, Abedi, KZ, Saito, Y, Borriello, F, Barman, S, Brook, B, Kelly, A, Menon, M, Marques-Mourlet, C, Gupta, MV, Lister, I, Oh, C, Lyskawa, K, Goetz, M, Walker, K, Cheng, WK, Brightman, SE, Sharma, P, O’Meara, TR, Chew, K, Vieira, D, Ryff, K, Sweitzer, C, Thomas, S, van Haren, SD, Pettengill, M, Seo, HS, Dhe-Paganon, S, Zhang, W, Levy, O & Dowling, DJ 2026, 'Discovery of a small molecule TLR3 agonist adjuvant', Nature Communications, vol. 17, no. 1, 364. https://doi.org/10.1038/s41467-025-66878-3

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title = "Discovery of a small molecule TLR3 agonist adjuvant",

author = "Branden Lee and Danica Dong and Etsuro Nanishi and Awad, \{John Mark\} and Abedi, \{Kimia Z.\} and Yoshine Saito and Francesco Borriello and Soumik Barman and Byron Brook and Aisling Kelly and Manisha Menon and Constance Marques-Mourlet and Gupta, \{Maansi V.\} and Ida Lister and Chiwoo Oh and Kevin Lyskawa and Morgan Goetz and Kristina Walker and Cheng, \{Wing Ki\} and Brightman, \{Spencer E.\} and Pankaj Sharma and O{\textquoteright}Meara, \{Timothy R.\} and Katherine Chew and Daniel Vieira and Kevin Ryff and Cali Sweitzer and Sanya Thomas and \{van Haren\}, \{Simon D.\} and Matthew Pettengill and Seo, \{Hyuk Soo\} and Sirano Dhe-Paganon and Wei Zhang and Ofer Levy and Dowling, \{David J.\}",

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doi = "10.1038/s41467-025-66878-3",

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AU - Lee, Branden

AU - Dong, Danica

AU - Nanishi, Etsuro

AU - Awad, John Mark

AU - Abedi, Kimia Z.

AU - Saito, Yoshine

AU - Borriello, Francesco

AU - Barman, Soumik

AU - Brook, Byron

AU - Kelly, Aisling

AU - Menon, Manisha

AU - Marques-Mourlet, Constance

AU - Gupta, Maansi V.

AU - Lister, Ida

AU - Oh, Chiwoo

AU - Lyskawa, Kevin

AU - Goetz, Morgan

AU - Walker, Kristina

AU - Cheng, Wing Ki

AU - Brightman, Spencer E.

AU - Sharma, Pankaj

AU - O’Meara, Timothy R.

AU - Chew, Katherine

AU - Vieira, Daniel

AU - Ryff, Kevin

AU - Sweitzer, Cali

AU - Thomas, Sanya

AU - van Haren, Simon D.

AU - Pettengill, Matthew

AU - Seo, Hyuk Soo

AU - Dhe-Paganon, Sirano

AU - Zhang, Wei

AU - Levy, Ofer

AU - Dowling, David J.

PY - 2026/12

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SN - 2041-1723

VL - 17

JO - Nature Communications

JF - Nature Communications

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Discovery of a small molecule TLR3 agonist adjuvant

ASJC Scopus Subject Areas

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