Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

Ioannis K. Zervantonakis; Matthew D. Poskus; Alexis L. Scott; Laura M. Selfors; Jia Ren Lin; Deborah A. Dillon; Shailja Pathania; Peter K. Sorger; Gordon B. Mills; Joan S. Brugge

doi:10.1073/pnas.2000648117

Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

Ioannis K. Zervantonakis
, Matthew D. Poskus
, Alexis L. Scott
, Laura M. Selfors
, Jia Ren Lin
, Deborah A. Dillon
, Shailja Pathania
, Peter K. Sorger
, Gordon B. Mills
, Joan S. Brugge

Biology

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	16500-16508
Number of pages	9
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	117
Issue number	28
DOIs	https://doi.org/10.1073/pnas.2000648117
State	Published - Jul 14 2020

ASJC Scopus Subject Areas

General

Keywords

Breast cancer
Cell–cell interactions
Drug resistance
Fibroblasts
Tumor microenvironment

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10.1073/pnas.2000648117

Cite this

Zervantonakis, I. K., Poskus, M. D., Scott, A. L., Selfors, L. M., Lin, J. R., Dillon, D. A., Pathania, S., Sorger, P. K., Mills, G. B., & Brugge, J. S. (2020). Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. Proceedings of the National Academy of Sciences of the United States of America, 117(28), 16500-16508. https://doi.org/10.1073/pnas.2000648117

Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. / Zervantonakis, Ioannis K.; Poskus, Matthew D.; Scott, Alexis L. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 28, 14.07.2020, p. 16500-16508.

Research output: Contribution to journal › Article › peer-review

Zervantonakis, IK, Poskus, MD, Scott, AL, Selfors, LM, Lin, JR, Dillon, DA, Pathania, S, Sorger, PK, Mills, GB & Brugge, JS 2020, 'Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 28, pp. 16500-16508. https://doi.org/10.1073/pnas.2000648117

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title = "Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways",

keywords = "Breast cancer, Cell–cell interactions, Drug resistance, Fibroblasts, Tumor microenvironment",

author = "Zervantonakis, \{Ioannis K.\} and Poskus, \{Matthew D.\} and Scott, \{Alexis L.\} and Selfors, \{Laura M.\} and Lin, \{Jia Ren\} and Dillon, \{Deborah A.\} and Shailja Pathania and Sorger, \{Peter K.\} and Mills, \{Gordon B.\} and Brugge, \{Joan S.\}",

year = "2020",

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doi = "10.1073/pnas.2000648117",

language = "English",

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AU - Zervantonakis, Ioannis K.

AU - Poskus, Matthew D.

AU - Scott, Alexis L.

AU - Selfors, Laura M.

AU - Lin, Jia Ren

AU - Dillon, Deborah A.

AU - Pathania, Shailja

AU - Sorger, Peter K.

AU - Mills, Gordon B.

AU - Brugge, Joan S.

PY - 2020/7/14

Y1 - 2020/7/14

KW - Breast cancer

KW - Cell–cell interactions

KW - Drug resistance

KW - Fibroblasts

KW - Tumor microenvironment

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AN - SCOPUS:85088179919

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

ASJC Scopus Subject Areas

Keywords

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