Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress

Shubhankar Nath; Michael Pigula; Amjad P. Khan; William Hanna; Mustafa Kemal Ruhi; Farzaneh Mahmoodpoor Dehkordy; Karthik Pushpavanam; Kaushal Rege; Kaitlin Moore; Yujiro Tsujita; Christina Conrad; Fatih Inci; Marcela G. Del Carmen; Walfre Franco; Jonathan P. Celli; Utkan Demirci; Tayyaba Hasan; Huang Chiao Huang; Imran Rizvi

doi:10.3390/jcm9040924

Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress

Shubhankar Nath
, Michael Pigula
, Amjad P. Khan
, William Hanna
, Mustafa Kemal Ruhi
, Farzaneh Mahmoodpoor Dehkordy
, Karthik Pushpavanam
, Kaushal Rege
, Kaitlin Moore
, Yujiro Tsujita
, Christina Conrad
, Fatih Inci
, Marcela G. Del Carmen
, Walfre Franco
, Jonathan P. Celli
, Utkan Demirci
, Tayyaba Hasan
, Huang Chiao Huang
, Imran Rizvi

Physics

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	924
Journal	Journal of Clinical Medicine
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/jcm9040924
State	Published - Apr 2020

ASJC Scopus Subject Areas

General Medicine

Keywords

Ascites
Carboplatin
Chemoresistance
Epidermal growth factor receptor (EGFR)
Extracellular signal-regulated kinase (ERK)
Fluid shear stress
Mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)
Ovarian cancer
Perfusion model
Photodynamic therapy (PDT)
Photoimmunotherapy (PIT)

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10.3390/jcm9040924

Cite this

Nath, S., Pigula, M., Khan, A. P., Hanna, W., Ruhi, M. K., Dehkordy, F. M., Pushpavanam, K., Rege, K., Moore, K., Tsujita, Y., Conrad, C., Inci, F., Del Carmen, M. G., Franco, W., Celli, J. P., Demirci, U., Hasan, T., Huang, H. C., & Rizvi, I. (2020). Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress. Journal of Clinical Medicine, 9(4), Article 924. https://doi.org/10.3390/jcm9040924

Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress. / Nath, Shubhankar; Pigula, Michael; Khan, Amjad P. et al.
In: Journal of Clinical Medicine, Vol. 9, No. 4, 924, 04.2020.

Research output: Contribution to journal › Article › peer-review

Nath, S, Pigula, M, Khan, AP, Hanna, W, Ruhi, MK, Dehkordy, FM, Pushpavanam, K, Rege, K, Moore, K, Tsujita, Y, Conrad, C, Inci, F, Del Carmen, MG, Franco, W, Celli, JP, Demirci, U, Hasan, T, Huang, HC & Rizvi, I 2020, 'Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress', Journal of Clinical Medicine, vol. 9, no. 4, 924. https://doi.org/10.3390/jcm9040924

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title = "Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress",

keywords = "Ascites, Carboplatin, Chemoresistance, Epidermal growth factor receptor (EGFR), Extracellular signal-regulated kinase (ERK), Fluid shear stress, Mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK), Ovarian cancer, Perfusion model, Photodynamic therapy (PDT), Photoimmunotherapy (PIT)",

author = "Shubhankar Nath and Michael Pigula and Khan, \{Amjad P.\} and William Hanna and Ruhi, \{Mustafa Kemal\} and Dehkordy, \{Farzaneh Mahmoodpoor\} and Karthik Pushpavanam and Kaushal Rege and Kaitlin Moore and Yujiro Tsujita and Christina Conrad and Fatih Inci and \{Del Carmen\}, \{Marcela G.\} and Walfre Franco and Celli, \{Jonathan P.\} and Utkan Demirci and Tayyaba Hasan and Huang, \{Huang Chiao\} and Imran Rizvi",

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month = apr,

doi = "10.3390/jcm9040924",

language = "English",

volume = "9",

journal = "Journal of Clinical Medicine",

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T1 - Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer

T2 - A role for EGFR-targeted photoimmunotherapy informed by physical stress

AU - Nath, Shubhankar

AU - Pigula, Michael

AU - Khan, Amjad P.

AU - Hanna, William

AU - Ruhi, Mustafa Kemal

AU - Dehkordy, Farzaneh Mahmoodpoor

AU - Pushpavanam, Karthik

AU - Rege, Kaushal

AU - Moore, Kaitlin

AU - Tsujita, Yujiro

AU - Conrad, Christina

AU - Inci, Fatih

AU - Del Carmen, Marcela G.

AU - Franco, Walfre

AU - Celli, Jonathan P.

AU - Demirci, Utkan

AU - Hasan, Tayyaba

AU - Huang, Huang Chiao

AU - Rizvi, Imran

PY - 2020/4

Y1 - 2020/4

KW - Ascites

KW - Carboplatin

KW - Chemoresistance

KW - Epidermal growth factor receptor (EGFR)

KW - Extracellular signal-regulated kinase (ERK)

KW - Fluid shear stress

KW - Mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK)

KW - Ovarian cancer

KW - Perfusion model

KW - Photodynamic therapy (PDT)

KW - Photoimmunotherapy (PIT)

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UR - https://www.scopus.com/pages/publications/85092456797#tab=citedBy

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DO - 10.3390/jcm9040924

M3 - Article

AN - SCOPUS:85092456797

SN - 2077-0383

VL - 9

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 4

M1 - 924

ER -

Flow-induced shear stress confers resistance to carboplatin in an adherent three-dimensional model for ovarian cancer: A role for EGFR-targeted photoimmunotherapy informed by physical stress

ASJC Scopus Subject Areas

Keywords

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