Fluorous linker-facilitated chemical synthesis

Fluorous linker-facilitated synthesis integrates the characteristics of solution-phase reactions and phase-tag-based separation. It has advantages of favorable homogeneous reaction kinetics, broad synthetic scope, easy monitoring of the reaction process, and compatibility with other synthetic and separation technologies. Complementary to the polymer linkers for solid-phase synthesis, the fluorous linkers have significantly enabled high-throughput synthesis and solution-phase chemistry. In addition to organic, medicinal, analytical, and separation applications, fluorous linker-based chemistry also has great potential in other areas such as biocatalysis, microarray, nanomaterial, green chemistry, and microfiuidic technologies.