Abstract
(Matrix presented) The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is substituted with 3-(trifluoromethyl)pyrazole followed by thioether oxidation and tag displacement with amines or thiols. The fluorous chain serves as a phase tag for intermediate and product purification over FluoroFlash SPE cartridges.
| Original language | English |
|---|---|
| Pages (from-to) | 1011-1013 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 5 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 3 2003 |
ASJC Scopus Subject Areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Fingerprint
Dive into the research topics of 'Fluorous synthesis of disubstituted pyrimidines'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS