Abstract
Fluorous proline derivatives generated from one-pot, three-component [3+2] cycloaddition of azomethine ylides are employed in different post-condensation reactions to form hydantoin-, piperazinedione-, and benzodiazepinedione-fused tricyclic and tetracyclic ring systems. High synthetic efficiency is achieved by conducting fast microwave reactions and purification by easy fluorous solid-phase extractions. Methods developed for these novel drug-like heterocyclic compounds can be applied to diversity-oriented library syntheses.
| Original language | English |
|---|---|
| Pages (from-to) | 2055-2059 |
| Number of pages | 5 |
| Journal | European Journal of Organic Chemistry |
| Issue number | 9 |
| DOIs | |
| State | Published - Apr 28 2006 |
ASJC Scopus Subject Areas
- Physical and Theoretical Chemistry
- Organic Chemistry
Keywords
- Cycloaddition
- Diversity-oriented synthesis
- Fluorous synthesis
- Microwave reaction
- Solid-phase extraction
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