Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones

Wei Zhang; John P. Williams; Yimin Lu; Tadamichi Nagashima; Qainli Chu

doi:10.1016/j.tetlet.2006.11.127

Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones

Wei Zhang
, John P. Williams
, Yimin Lu
, Tadamichi Nagashima
, Qainli Chu

Chemistry

University of Pittsburgh
Neurocrine Biosciences Incorporated

Research output: Contribution to journal › Article › peer-review

Abstract

A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for the synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).

Original language	English
Pages (from-to)	563-565
Number of pages	3
Journal	Tetrahedron Letters
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2006.11.127
State	Published - Jan 22 2007

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

1,4-Benzodiazepine-2,5-dione
Benzodiazepine-quinazolinone
Fluorous synthesis
Sclerotigenin
Solid-phase extraction

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10.1016/j.tetlet.2006.11.127

Cite this

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title = "Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones",

abstract = "A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for the synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).",

keywords = "1,4-Benzodiazepine-2,5-dione, Benzodiazepine-quinazolinone, Fluorous synthesis, Sclerotigenin, Solid-phase extraction",

author = "Wei Zhang and Williams, \{John P.\} and Yimin Lu and Tadamichi Nagashima and Qainli Chu",

year = "2007",

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language = "English",

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T1 - Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones

AU - Zhang, Wei

AU - Williams, John P.

AU - Lu, Yimin

AU - Nagashima, Tadamichi

AU - Chu, Qainli

PY - 2007/1/22

Y1 - 2007/1/22

N2 - A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for the synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).

AB - A new synthetic protocol for sclerotigenin-type benzodiazepine-quinazolinone library scaffold is introduced. A fluorous benzyl protecting group is used for the synthesis of 4-benzodiazepine-2,5-dione intermediate and also as a phase tag for fluorous solid-phase extraction (F-SPE).

KW - 1,4-Benzodiazepine-2,5-dione

KW - Benzodiazepine-quinazolinone

KW - Fluorous synthesis

KW - Sclerotigenin

KW - Solid-phase extraction

UR - https://www.scopus.com/pages/publications/33845631970

UR - https://www.scopus.com/pages/publications/33845631970#tab=citedBy

U2 - 10.1016/j.tetlet.2006.11.127

DO - 10.1016/j.tetlet.2006.11.127

M3 - Article

AN - SCOPUS:33845631970

SN - 0040-4039

VL - 48

SP - 563

EP - 565

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones

Abstract

ASJC Scopus Subject Areas

Keywords

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