Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors

Vignesh Shanmugam; Neriman Tokcan; Daniel Chafamo; Sean Sullivan; Mehdi Borji; Haley Martin; Gail Newton; Naeem Nadaf; Saoirse Hanbury; Irving Barrera; Dylan Cable; Jackson Weir; Orr Ashenberg; Geraldine Pinkus; Scott Rodig; Caroline Uhler; Evan Macosko; Margaret Shipp; Abner Louissaint; Fei Chen; Todd R. Golub

doi:10.1038/s41467-025-67539-1

Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors

Vignesh Shanmugam
, Neriman Tokcan
, Daniel Chafamo
, Sean Sullivan
, Mehdi Borji
, Haley Martin
, Gail Newton
, Naeem Nadaf
, Saoirse Hanbury
, Irving Barrera
, Dylan Cable
, Jackson Weir
, Orr Ashenberg
, Geraldine Pinkus
, Scott Rodig
, Caroline Uhler
, Evan Macosko
, Margaret Shipp
, Abner Louissaint
, Fei Chen

Todd R. Golub

Mathematics

Broad Institute
Brigham and Women’s Hospital
Harvard University
University of Pennsylvania
The University of Chicago
Massachusetts General Hospital
University of Michigan, Ann Arbor
Massachusetts Institute of Technology
Dana-Farber Cancer Institute
Harvard University

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	838
Journal	Nature Communications
Volume	17
Issue number	1
DOIs	https://doi.org/10.1038/s41467-025-67539-1
State	Published - Dec 2026

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General
General Physics and Astronomy

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10.1038/s41467-025-67539-1

Cite this

Shanmugam, V., Tokcan, N., Chafamo, D., Sullivan, S., Borji, M., Martin, H., Newton, G., Nadaf, N., Hanbury, S., Barrera, I., Cable, D., Weir, J., Ashenberg, O., Pinkus, G., Rodig, S., Uhler, C., Macosko, E., Shipp, M., Louissaint, A., ... Golub, T. R. (2026). Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. Nature Communications, 17(1), Article 838. https://doi.org/10.1038/s41467-025-67539-1

Shanmugam, V, Tokcan, N, Chafamo, D, Sullivan, S, Borji, M, Martin, H, Newton, G, Nadaf, N, Hanbury, S, Barrera, I, Cable, D, Weir, J, Ashenberg, O, Pinkus, G, Rodig, S, Uhler, C, Macosko, E, Shipp, M, Louissaint, A, Chen, F & Golub, TR 2026, 'Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors', Nature Communications, vol. 17, no. 1, 838. https://doi.org/10.1038/s41467-025-67539-1

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AU - Shanmugam, Vignesh

AU - Tokcan, Neriman

AU - Chafamo, Daniel

AU - Sullivan, Sean

AU - Borji, Mehdi

AU - Martin, Haley

AU - Newton, Gail

AU - Nadaf, Naeem

AU - Hanbury, Saoirse

AU - Barrera, Irving

AU - Cable, Dylan

AU - Weir, Jackson

AU - Ashenberg, Orr

AU - Pinkus, Geraldine

AU - Rodig, Scott

AU - Uhler, Caroline

AU - Macosko, Evan

AU - Shipp, Margaret

AU - Louissaint, Abner

AU - Chen, Fei

AU - Golub, Todd R.

PY - 2026/12

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SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

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Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors

ASJC Scopus Subject Areas

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