High-density encapsulation of Fe3O4 nanoparticles in lipid vesicles

Andy Wijaya; Kimberly Hamad-Schifferli

doi:10.1021/la701128b

High-density encapsulation of Fe₃O₄ nanoparticles in lipid vesicles

Andy Wijaya
, Kimberly Hamad-Schifferli

Engineering

Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

We report a morphological study of the encapsulation of 12-nm Fe ₃O₄ nanoparticles (NPs) in large unilamellar vesicles of dipalmitoylphosphatidylcholine (DPPC). Preparation was done by reverse-phase evaporation. Phase behavior of the NP-lipid system was studied so that the loading of NPs in vesicles could be maximized. Increasing NP concentration significantly affects the resulting lipid morphology in a manner similar to increasing lipid concentration. Optimal production of high-density NP-loaded vesicles (HNLVs) requires temperatures of 50° C, higher than the main phase transition (T_m) of DPPC. The formation of fully enclosed HNLVs requires incubation times of at least hours.

Original language	English
Pages (from-to)	9546-9550
Number of pages	5
Journal	Langmuir
Volume	23
Issue number	19
DOIs	https://doi.org/10.1021/la701128b
State	Published - Sep 11 2007

ASJC Scopus Subject Areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la701128b

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AB - We report a morphological study of the encapsulation of 12-nm Fe 3O4 nanoparticles (NPs) in large unilamellar vesicles of dipalmitoylphosphatidylcholine (DPPC). Preparation was done by reverse-phase evaporation. Phase behavior of the NP-lipid system was studied so that the loading of NPs in vesicles could be maximized. Increasing NP concentration significantly affects the resulting lipid morphology in a manner similar to increasing lipid concentration. Optimal production of high-density NP-loaded vesicles (HNLVs) requires temperatures of 50° C, higher than the main phase transition (Tm) of DPPC. The formation of fully enclosed HNLVs requires incubation times of at least hours.

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High-density encapsulation of Fe₃O₄ nanoparticles in lipid vesicles

Abstract

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