Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress

Yiji Liao; Chen Hao Chen; Tengfei Xiao; Bárbara de la Peña Avalos; Eloise V. Dray; Changmeng Cai; Shuai Gao; Neel Shah; Zhao Zhang; Avery Feit; Pengya Xue; Zhijie Liu; Mei Yang; Ji Hoon Lee; Han Xu; Wei Li; Shenglin Mei; Roodolph S. Pierre; Shaokun Shu; Teng Fei; Melissa Duarte; Jin Zhao; James E. Bradner; Kornelia Polyak; Philip W. Kantoff; Henry Long; Steven P. Balk; X. Shirley Liu; Myles Brown; Kexin Xu

doi:10.1073/pnas.2105898119

Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress

Yiji Liao
, Chen Hao Chen
, Tengfei Xiao
, Bárbara de la Peña Avalos
, Eloise V. Dray
, Changmeng Cai
, Shuai Gao
, Neel Shah
, Zhao Zhang
, Avery Feit
, Pengya Xue
, Zhijie Liu
, Mei Yang
, Ji Hoon Lee
, Han Xu
, Wei Li
, Shenglin Mei
, Roodolph S. Pierre
, Shaokun Shu
, Teng Fei

Melissa Duarte, Jin Zhao, James E. Bradner, Kornelia Polyak, Philip W. Kantoff, Henry Long, Steven P. Balk, X. Shirley Liu, Myles Brown, Kexin Xu

Biology

University of Texas Health Science Center at San Antonio
Dana-Farber Cancer Institute
Harvard University
University of Massachusetts Boston
Beth Israel Deaconess Medical Center

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e2105898119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	3
DOIs	https://doi.org/10.1073/pnas.2105898119
State	Published - Jan 18 2022

ASJC Scopus Subject Areas

General

Keywords

Cancer therapy
DNA damage repair
EZH2 inhibitors
Mechanism of drug action

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10.1073/pnas.2105898119

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Liao, Y., Chen, C. H., Xiao, T., de la Peña Avalos, B., Dray, E. V., Cai, C., Gao, S., Shah, N., Zhang, Z., Feit, A., Xue, P., Liu, Z., Yang, M., Lee, J. H., Xu, H., Li, W., Mei, S., Pierre, R. S., Shu, S., ... Xu, K. (2022). Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America, 119(3), Article e2105898119. https://doi.org/10.1073/pnas.2105898119

Liao, Y, Chen, CH, Xiao, T, de la Peña Avalos, B, Dray, EV, Cai, C, Gao, S, Shah, N, Zhang, Z, Feit, A, Xue, P, Liu, Z, Yang, M, Lee, JH, Xu, H, Li, W, Mei, S, Pierre, RS, Shu, S, Fei, T, Duarte, M, Zhao, J, Bradner, JE, Polyak, K, Kantoff, PW, Long, H, Balk, SP, Liu, XS, Brown, M & Xu, K 2022, 'Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 3, e2105898119. https://doi.org/10.1073/pnas.2105898119

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keywords = "Cancer therapy, DNA damage repair, EZH2 inhibitors, Mechanism of drug action",

author = "Yiji Liao and Chen, \{Chen Hao\} and Tengfei Xiao and \{de la Pe{\~n}a Avalos\}, B{\'a}rbara and Dray, \{Eloise V.\} and Changmeng Cai and Shuai Gao and Neel Shah and Zhao Zhang and Avery Feit and Pengya Xue and Zhijie Liu and Mei Yang and Lee, \{Ji Hoon\} and Han Xu and Wei Li and Shenglin Mei and Pierre, \{Roodolph S.\} and Shaokun Shu and Teng Fei and Melissa Duarte and Jin Zhao and Bradner, \{James E.\} and Kornelia Polyak and Kantoff, \{Philip W.\} and Henry Long and Balk, \{Steven P.\} and Liu, \{X. Shirley\} and Myles Brown and Kexin Xu",

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AU - Liao, Yiji

AU - Chen, Chen Hao

AU - Xiao, Tengfei

AU - de la Peña Avalos, Bárbara

AU - Dray, Eloise V.

AU - Cai, Changmeng

AU - Gao, Shuai

AU - Shah, Neel

AU - Zhang, Zhao

AU - Feit, Avery

AU - Xue, Pengya

AU - Liu, Zhijie

AU - Yang, Mei

AU - Lee, Ji Hoon

AU - Xu, Han

AU - Li, Wei

AU - Mei, Shenglin

AU - Pierre, Roodolph S.

AU - Shu, Shaokun

AU - Fei, Teng

AU - Duarte, Melissa

AU - Zhao, Jin

AU - Bradner, James E.

AU - Polyak, Kornelia

AU - Kantoff, Philip W.

AU - Long, Henry

AU - Balk, Steven P.

AU - Liu, X. Shirley

AU - Brown, Myles

AU - Xu, Kexin

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PY - 2022/1/18

Y1 - 2022/1/18

KW - Cancer therapy

KW - DNA damage repair

KW - EZH2 inhibitors

KW - Mechanism of drug action

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Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress

ASJC Scopus Subject Areas

Keywords

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