Abstract
Cocaine- and amphetamine-regulated transcript (CART) peptides are found in brain and spinal cord areas involved in pain transmission. In the present study, we investigated the role of rat CART (55-102) in the modulation of an acute pain model after intrathecal administration. The results show that CART (55-102) was without effect on the tail-flick test after i.t. injection in mice. Interestingly, i.t. administration of CART (55-102) significantly enhanced the antinociceptive effect of morphine in the tail-flick test. These results suggest that CART (55-102) potentiates the effects of opioids to inhibit the nociceptive information transmission.
| Original language | English |
|---|---|
| Pages (from-to) | 146-149 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 1024 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 22 2004 |
ASJC Scopus Subject Areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Keywords
- Brain
- Cocaine
- Spinal cord
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