Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

Changmeng Cai; Sen Chen; Patrick Ng; Glenn J. Bubley; Peter S. Nelson; Elahe A. Mostaghel; Brett Marck; Alvin M. Matsumoto; Nicholas I. Simon; Hongyun Wang; Shaoyong Chen; Steven P. Balk

doi:10.1158/0008-5472.CAN-11-0532

Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

Changmeng Cai
, Sen Chen
, Patrick Ng
, Glenn J. Bubley
, Peter S. Nelson
, Elahe A. Mostaghel
, Brett Marck
, Alvin M. Matsumoto
, Nicholas I. Simon
, Hongyun Wang
, Shaoyong Chen
, Steven P. Balk

Biology

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	6503-6513
Number of pages	11
Journal	Cancer Research
Volume	71
Issue number	20
DOIs	https://doi.org/10.1158/0008-5472.CAN-11-0532
State	Published - Oct 15 2011

ASJC Scopus Subject Areas

Oncology
Cancer Research

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10.1158/0008-5472.CAN-11-0532

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Cai, C., Chen, S., Ng, P., Bubley, G. J., Nelson, P. S., Mostaghel, E. A., Marck, B., Matsumoto, A. M., Simon, N. I., Wang, H., Chen, S., & Balk, S. P. (2011). Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Research, 71(20), 6503-6513. https://doi.org/10.1158/0008-5472.CAN-11-0532

Cai, C, Chen, S, Ng, P, Bubley, GJ, Nelson, PS, Mostaghel, EA, Marck, B, Matsumoto, AM, Simon, NI, Wang, H, Chen, S & Balk, SP 2011, 'Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors', Cancer Research, vol. 71, no. 20, pp. 6503-6513. https://doi.org/10.1158/0008-5472.CAN-11-0532

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title = "Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors",

author = "Changmeng Cai and Sen Chen and Patrick Ng and Bubley, \{Glenn J.\} and Nelson, \{Peter S.\} and Mostaghel, \{Elahe A.\} and Brett Marck and Matsumoto, \{Alvin M.\} and Simon, \{Nicholas I.\} and Hongyun Wang and Shaoyong Chen and Balk, \{Steven P.\}",

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T1 - Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

AU - Cai, Changmeng

AU - Chen, Sen

AU - Ng, Patrick

AU - Bubley, Glenn J.

AU - Nelson, Peter S.

AU - Mostaghel, Elahe A.

AU - Marck, Brett

AU - Matsumoto, Alvin M.

AU - Simon, Nicholas I.

AU - Wang, Hongyun

AU - Chen, Shaoyong

AU - Balk, Steven P.

PY - 2011/10/15

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M3 - Article

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AN - SCOPUS:80054021222

SN - 0008-5472

VL - 71

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JO - Cancer Research

JF - Cancer Research

IS - 20

ER -

Intratumoral De Novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

ASJC Scopus Subject Areas

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