Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

Zijuan Zhang; Nicholas Kwiatkowski; Hong Zeng; Sang Min Lim; Nathanael S. Gray; Wei Zhang; Priscilla L. Yang

doi:10.1039/c2mb25099c

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

Zijuan Zhang
, Nicholas Kwiatkowski
, Hong Zeng
, Sang Min Lim
, Nathanael S. Gray
, Wei Zhang
, Priscilla L. Yang

Chemistry

University of Massachusetts Boston
Harvard University

Research output: Contribution to journal › Article › peer-review

Abstract

As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

Original language	English
Pages (from-to)	2523-2526
Number of pages	4
Journal	Molecular BioSystems
Volume	8
Issue number	10
DOIs	https://doi.org/10.1039/c2mb25099c
State	Published - Oct 2012

ASJC Scopus Subject Areas

Biotechnology
Molecular Biology

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10.1039/c2mb25099c

Cite this

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title = "Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy",

abstract = "As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.",

author = "Zijuan Zhang and Nicholas Kwiatkowski and Hong Zeng and Lim, \{Sang Min\} and Gray, \{Nathanael S.\} and Wei Zhang and Yang, \{Priscilla L.\}",

year = "2012",

month = oct,

doi = "10.1039/c2mb25099c",

language = "English",

volume = "8",

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journal = "Molecular BioSystems",

issn = "1742-206X",

publisher = "Royal Society of Chemistry",

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AU - Zhang, Zijuan

AU - Kwiatkowski, Nicholas

AU - Zeng, Hong

AU - Lim, Sang Min

AU - Gray, Nathanael S.

AU - Zhang, Wei

AU - Yang, Priscilla L.

PY - 2012/10

Y1 - 2012/10

N2 - As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

AB - As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

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UR - https://www.scopus.com/pages/publications/84865718745#tab=citedBy

U2 - 10.1039/c2mb25099c

DO - 10.1039/c2mb25099c

M3 - Article

C2 - 22673640

AN - SCOPUS:84865718745

SN - 1742-206X

VL - 8

SP - 2523

EP - 2526

JO - Molecular BioSystems

JF - Molecular BioSystems

IS - 10

ER -

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

Abstract

ASJC Scopus Subject Areas

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