MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas

Ophélia Maertens; Ryan Kuzmickas; Haley E. Manchester; Chloe E. Emerson; Alessandra G. Gavin; Caroline J. Guild; Terence C. Wong; Thomas de Raedt; Christian Bowman-Colin; Elodie Hatchi; Levi A. Garraway; Keith T. Flaherty; Shailja Pathania; Stephen J. Elledge; Karen Cichowski

doi:10.1158/2159-8290.CD-18-0879

MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas

Ophélia Maertens
, Ryan Kuzmickas
, Haley E. Manchester
, Chloe E. Emerson
, Alessandra G. Gavin
, Caroline J. Guild
, Terence C. Wong
, Thomas de Raedt
, Christian Bowman-Colin
, Elodie Hatchi
, Levi A. Garraway
, Keith T. Flaherty
, Shailja Pathania
, Stephen J. Elledge
, Karen Cichowski

Biology

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	526-545
Number of pages	20
Journal	Cancer Discovery
Volume	9
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-18-0879
State	Published - Apr 2019

ASJC Scopus Subject Areas

Oncology

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10.1158/2159-8290.CD-18-0879

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Maertens, O., Kuzmickas, R., Manchester, H. E., Emerson, C. E., Gavin, A. G., Guild, C. J., Wong, T. C., de Raedt, T., Bowman-Colin, C., Hatchi, E., Garraway, L. A., Flaherty, K. T., Pathania, S., Elledge, S. J., & Cichowski, K. (2019). MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas. Cancer Discovery, 9(4), 526-545. https://doi.org/10.1158/2159-8290.CD-18-0879

Maertens, O, Kuzmickas, R, Manchester, HE, Emerson, CE, Gavin, AG, Guild, CJ, Wong, TC, de Raedt, T, Bowman-Colin, C, Hatchi, E, Garraway, LA, Flaherty, KT, Pathania, S, Elledge, SJ & Cichowski, K 2019, 'MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas', Cancer Discovery, vol. 9, no. 4, pp. 526-545. https://doi.org/10.1158/2159-8290.CD-18-0879

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title = "MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas",

author = "Oph{\'e}lia Maertens and Ryan Kuzmickas and Manchester, \{Haley E.\} and Emerson, \{Chloe E.\} and Gavin, \{Alessandra G.\} and Guild, \{Caroline J.\} and Wong, \{Terence C.\} and \{de Raedt\}, Thomas and Christian Bowman-Colin and Elodie Hatchi and Garraway, \{Levi A.\} and Flaherty, \{Keith T.\} and Shailja Pathania and Elledge, \{Stephen J.\} and Karen Cichowski",

note = "Publisher Copyright: {\textcopyright} 2019 American Association for Cancer Research.",

year = "2019",

month = apr,

doi = "10.1158/2159-8290.CD-18-0879",

language = "English",

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T1 - MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas

AU - Maertens, Ophélia

AU - Kuzmickas, Ryan

AU - Manchester, Haley E.

AU - Emerson, Chloe E.

AU - Gavin, Alessandra G.

AU - Guild, Caroline J.

AU - Wong, Terence C.

AU - de Raedt, Thomas

AU - Bowman-Colin, Christian

AU - Hatchi, Elodie

AU - Garraway, Levi A.

AU - Flaherty, Keith T.

AU - Pathania, Shailja

AU - Elledge, Stephen J.

AU - Cichowski, Karen

PY - 2019/4

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UR - https://www.scopus.com/pages/publications/85064193376

UR - https://www.scopus.com/pages/publications/85064193376#tab=citedBy

U2 - 10.1158/2159-8290.CD-18-0879

DO - 10.1158/2159-8290.CD-18-0879

M3 - Article

C2 - 30709805

AN - SCOPUS:85064193376

SN - 2159-8274

VL - 9

SP - 526

EP - 545

JO - Cancer Discovery

JF - Cancer Discovery

IS - 4

ER -

MAPK pathway suppression unmasks latent dna repair defects and confers a chemical synthetic vulnerability in BRAF-, NRAS-, and NF1 -mutant melanomas

ASJC Scopus Subject Areas

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