Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Pei Zhi Zhang; Jian An Li; Ling Zhang; Adedamola Shoberu; Jian Ping Zou; Wei Zhang

doi:10.1039/c6gc03355e

Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Pei Zhi Zhang
, Jian An Li
, Ling Zhang
, Adedamola Shoberu
, Jian Ping Zou
, Wei Zhang

Chemistry

Soochow University

Research output: Contribution to journal › Article › peer-review

Abstract

A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

Original language	English
Pages (from-to)	919-923
Number of pages	5
Journal	Green Chemistry
Volume	19
Issue number	4
DOIs	https://doi.org/10.1039/c6gc03355e
State	Published - 2017

ASJC Scopus Subject Areas

Environmental Chemistry
Pollution

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10.1039/c6gc03355e

Cite this

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title = "Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide",

abstract = "A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.",

author = "Zhang, \{Pei Zhi\} and Li, \{Jian An\} and Ling Zhang and Adedamola Shoberu and Zou, \{Jian Ping\} and Wei Zhang",

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year = "2017",

doi = "10.1039/c6gc03355e",

language = "English",

volume = "19",

pages = "919--923",

journal = "Green Chemistry",

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T1 - Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

AU - Zhang, Pei Zhi

AU - Li, Jian An

AU - Zhang, Ling

AU - Shoberu, Adedamola

AU - Zou, Jian Ping

AU - Zhang, Wei

N1 - Publisher Copyright: © The Royal Society of Chemistry 2017.

PY - 2017

Y1 - 2017

N2 - A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

AB - A new method for free radical methylation of pyrimidinones and pyridinones with dicumyl peroxide (DCP) under metal-free conditions is introduced. A 50 g-scale reaction could be performed safely at the desired concentration. The reaction solvent and DCP derivative were readily recovered by distillation. The product was purified by crystallization to minimize the amount of waste.

UR - https://www.scopus.com/pages/publications/85016319922

UR - https://www.scopus.com/pages/publications/85016319922#tab=citedBy

U2 - 10.1039/c6gc03355e

DO - 10.1039/c6gc03355e

M3 - Article

AN - SCOPUS:85016319922

SN - 1463-9262

VL - 19

SP - 919

EP - 923

JO - Green Chemistry

JF - Green Chemistry

IS - 4

ER -

Metal-free radical C-H methylation of pyrimidinones and pyridinones with dicumyl peroxide

Abstract

ASJC Scopus Subject Areas

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