@inproceedings{c2f0aeb4110e4ecc8491261a54af86bc,
title = "Modeling stromal determinants of 3D tumor growth to inform PDT-mediated combination treatments",
abstract = "Advanced stage ovarian carcinoma is characterized by poor prognosis and peritoneal micronodules that exhibit treatment resistance. This is partially due to interactions between multifocal disease and the tumor microenvironment, which includes tumor endothelial cells (TECs) and extracellular matrix components (ECM). Here we describe the development of a three-dimensional model of ovarian cancer that incorporates TECs and ECM. A comparison of several methodologies to generate endothelialized ovarian micronodules along with a preliminary physical characterization is described. This model will allow for detailed investigation of tumor-stroma interactions and how they impact disease progression and treatment response.",
keywords = "Extracellular Matrix, Ovarian Cancer, Three-dimensional heterocellular model, Tumor Endothelial Cells, tumor microenvironment",
author = "I. Rizvi and S. Anbil and Celli, \{J. P.\} and N. Alagic and I. Massodi and T. Hasan",
year = "2013",
doi = "10.1117/12.2010678",
language = "English",
isbn = "9780819493378",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Methods for Tumor Treatment and Detection",
note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII ; Conference date: 02-02-2013 Through 04-02-2013",
}