No association between unintentional head injuries and early-life exposure to tetrachloroethylene (PCE)-contaminated drinking water

Objective: Because of emerging evidence that early-life exposure to the solvent tetrachloroethylene (PCE) has long-lasting neurological consequences, we examined the risk of unintentional head injuries following prenatal and childhood exposure to PCE-contaminated drinking water. Methods: Participants provided information on head injuries and other relevant characteristics in a self-Administered questionnaire. Exposure to PCE was modeled using a leaching and transport algorithm set in water system modeling software. Results: We did not observe any evidence of an increased risk of any type of head injury among exposed participants. Conclusions: PCE is a widespread water pollutant. Thus, documenting possible health effects of early-life exposure is vital for ensuring that drinking water regulations adequately protect vulnerable populations.