One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds

Fluorination followed by the Michael addition or Robinson annulation of 1,3-dicarbonyl compounds is introduced for the synthesis of acyclic and cyclic α-fluoro-β-ketoesters and α-fluoro-1,3-diketones. The decarboxylation step can also be added to the reaction sequence. High efficiency is achieved by the microwave heating and atom economic one-pot synthesis.