One-Pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines

Zhidong Song; Xin Huang; Wenbin Yi; Wei Zhang

doi:10.1021/acs.orglett.6b02883

One-Pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines

Zhidong Song
, Xin Huang
, Wenbin Yi
, Wei Zhang

Chemistry

Nanjing University of Science and Technology
University of Massachusetts Boston

Research output: Contribution to journal › Article › peer-review

Abstract

A 2-fluoro-1,3-dicarbonyl-initiated one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence is introduced for regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines as well as fused pyridines. This simple and modular synthesis is performed using readily available starting materials and under transition-metal catalyst-free conditions.

Original language	English
Pages (from-to)	5640-5643
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	21
DOIs	https://doi.org/10.1021/acs.orglett.6b02883
State	Published - Nov 4 2016

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.6b02883

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abstract = "A 2-fluoro-1,3-dicarbonyl-initiated one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence is introduced for regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines as well as fused pyridines. This simple and modular synthesis is performed using readily available starting materials and under transition-metal catalyst-free conditions.",

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AU - Yi, Wenbin

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Y1 - 2016/11/4

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AB - A 2-fluoro-1,3-dicarbonyl-initiated one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence is introduced for regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines as well as fused pyridines. This simple and modular synthesis is performed using readily available starting materials and under transition-metal catalyst-free conditions.

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One-Pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines

Abstract

ASJC Scopus Subject Areas

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