One-pot synthesis of triazolobenzodiazepines through decarboxylative [3 + 2] cycloaddition of nonstabilized azomethine ylides and Cu-free click reactions

Xiaoming Ma; Xiaofeng Zhang; Weiqi Qiu; Wensheng Zhang; Bruce Wan; Jason Evans; Wei Zhang

doi:10.3390/molecules24030601

One-pot synthesis of triazolobenzodiazepines through decarboxylative [3 + 2] cycloaddition of nonstabilized azomethine ylides and Cu-free click reactions

Xiaoming Ma
, Xiaofeng Zhang
, Weiqi Qiu
, Wensheng Zhang
, Bruce Wan
, Jason Evans
, Wei Zhang

Chemistry

Changzhou University
University of Massachusetts Boston
Jiaozuo Teachers’ College

Research output: Contribution to journal › Article › peer-review

Abstract

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.

Original language	English
Article number	601
Journal	Molecules
Volume	24
Issue number	3
DOIs	https://doi.org/10.3390/molecules24030601
State	Published - Feb 8 2019

ASJC Scopus Subject Areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Keywords

Click reaction
Decarboxylative [3 + 2] cycloaddition
Nonstabilized azomethine ylides
One-pot synthesis

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10.3390/molecules24030601

Cite this

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title = "One-pot synthesis of triazolobenzodiazepines through decarboxylative [3 + 2] cycloaddition of nonstabilized azomethine ylides and Cu-free click reactions",

abstract = "A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.",

keywords = "Click reaction, Decarboxylative [3 + 2] cycloaddition, Nonstabilized azomethine ylides, One-pot synthesis",

author = "Xiaoming Ma and Xiaofeng Zhang and Weiqi Qiu and Wensheng Zhang and Bruce Wan and Jason Evans and Wei Zhang",

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doi = "10.3390/molecules24030601",

language = "English",

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T1 - One-pot synthesis of triazolobenzodiazepines through decarboxylative [3 + 2] cycloaddition of nonstabilized azomethine ylides and Cu-free click reactions

AU - Ma, Xiaoming

AU - Zhang, Xiaofeng

AU - Qiu, Weiqi

AU - Zhang, Wensheng

AU - Wan, Bruce

AU - Evans, Jason

AU - Zhang, Wei

PY - 2019/2/8

Y1 - 2019/2/8

N2 - A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.

AB - A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.

KW - Click reaction

KW - Decarboxylative [3 + 2] cycloaddition

KW - Nonstabilized azomethine ylides

KW - One-pot synthesis

UR - https://www.scopus.com/pages/publications/85061404632

UR - https://www.scopus.com/pages/publications/85061404632#tab=citedBy

U2 - 10.3390/molecules24030601

DO - 10.3390/molecules24030601

M3 - Article

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AN - SCOPUS:85061404632

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 3

M1 - 601

ER -

One-pot synthesis of triazolobenzodiazepines through decarboxylative [3 + 2] cycloaddition of nonstabilized azomethine ylides and Cu-free click reactions

Abstract

ASJC Scopus Subject Areas

Keywords

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