PrEP Uptake and Discontinuation Among a U.S. National Sample of Transgender Men and Women

Meagan Zarwell; Steven A. John; Drew Westmoreland; Chloe Mirzayi; David W. Pantalone; Sarit Golub; Denis Nash; Christian Grov

doi:10.1007/s10461-020-03064-0

PrEP Uptake and Discontinuation Among a U.S. National Sample of Transgender Men and Women

Meagan Zarwell
, Steven A. John
, Drew Westmoreland
, Chloe Mirzayi
, David W. Pantalone
, Sarit Golub
, Denis Nash
, Christian Grov

CLA - Dean's Office

University of North Carolina at Charlotte
Medical College of Wisconsin
City University of New York

Research output: Contribution to journal › Article › peer-review

Abstract

Pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention efforts by effectively preventing the sexual transmission of HIV infection. Few studies have examined PrEP uptake and discontinuation among transgender individuals who are underserved in HIV prevention efforts. An online U.S. nationwide survey screened 294 HIV-negative transgender people for participation in a larger cohort study. We analyzed associations between demographic characteristics and PrEP use and discontinuation. We conducted thematic analyses of open-ended responses to identify reasons for PrEP discontinuation. Fifty-one participants (17.4%) reported ever receiving a PrEP prescription. Transgender men reported higher PrEP use than transgender women (χ² = 18.06; p < 0.0001). PrEP discontinuation was reported by 49.0% of individuals who reported PrEP use. Reasons for PrEP discontinuation were related to side effects, insurance coverage, relationship status, and access to providers. HIV prevention efforts to increase PrEP should include mechanisms for PrEP uptake and re-initiation among transgender individuals.

Original language	English
Pages (from-to)	1063-1071
Number of pages	9
Journal	AIDS and Behavior
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/s10461-020-03064-0
State	Published - Apr 2021

ASJC Scopus Subject Areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

Keywords

Discontinuation
HIV prevention
PrEP
Transgender
Uptake

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10.1007/s10461-020-03064-0

Cite this

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title = "PrEP Uptake and Discontinuation Among a U.S. National Sample of Transgender Men and Women",

abstract = "Pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention efforts by effectively preventing the sexual transmission of HIV infection. Few studies have examined PrEP uptake and discontinuation among transgender individuals who are underserved in HIV prevention efforts. An online U.S. nationwide survey screened 294 HIV-negative transgender people for participation in a larger cohort study. We analyzed associations between demographic characteristics and PrEP use and discontinuation. We conducted thematic analyses of open-ended responses to identify reasons for PrEP discontinuation. Fifty-one participants (17.4\%) reported ever receiving a PrEP prescription. Transgender men reported higher PrEP use than transgender women (χ2 = 18.06; p < 0.0001). PrEP discontinuation was reported by 49.0\% of individuals who reported PrEP use. Reasons for PrEP discontinuation were related to side effects, insurance coverage, relationship status, and access to providers. HIV prevention efforts to increase PrEP should include mechanisms for PrEP uptake and re-initiation among transgender individuals.",

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author = "Meagan Zarwell and John, \{Steven A.\} and Drew Westmoreland and Chloe Mirzayi and Pantalone, \{David W.\} and Sarit Golub and Denis Nash and Christian Grov",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2021",

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doi = "10.1007/s10461-020-03064-0",

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AU - Mirzayi, Chloe

AU - Pantalone, David W.

AU - Golub, Sarit

AU - Nash, Denis

AU - Grov, Christian

PY - 2021/4

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N2 - Pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention efforts by effectively preventing the sexual transmission of HIV infection. Few studies have examined PrEP uptake and discontinuation among transgender individuals who are underserved in HIV prevention efforts. An online U.S. nationwide survey screened 294 HIV-negative transgender people for participation in a larger cohort study. We analyzed associations between demographic characteristics and PrEP use and discontinuation. We conducted thematic analyses of open-ended responses to identify reasons for PrEP discontinuation. Fifty-one participants (17.4%) reported ever receiving a PrEP prescription. Transgender men reported higher PrEP use than transgender women (χ2 = 18.06; p < 0.0001). PrEP discontinuation was reported by 49.0% of individuals who reported PrEP use. Reasons for PrEP discontinuation were related to side effects, insurance coverage, relationship status, and access to providers. HIV prevention efforts to increase PrEP should include mechanisms for PrEP uptake and re-initiation among transgender individuals.

AB - Pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention efforts by effectively preventing the sexual transmission of HIV infection. Few studies have examined PrEP uptake and discontinuation among transgender individuals who are underserved in HIV prevention efforts. An online U.S. nationwide survey screened 294 HIV-negative transgender people for participation in a larger cohort study. We analyzed associations between demographic characteristics and PrEP use and discontinuation. We conducted thematic analyses of open-ended responses to identify reasons for PrEP discontinuation. Fifty-one participants (17.4%) reported ever receiving a PrEP prescription. Transgender men reported higher PrEP use than transgender women (χ2 = 18.06; p < 0.0001). PrEP discontinuation was reported by 49.0% of individuals who reported PrEP use. Reasons for PrEP discontinuation were related to side effects, insurance coverage, relationship status, and access to providers. HIV prevention efforts to increase PrEP should include mechanisms for PrEP uptake and re-initiation among transgender individuals.

KW - Discontinuation

KW - HIV prevention

KW - PrEP

KW - Transgender

KW - Uptake

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ER -

PrEP Uptake and Discontinuation Among a U.S. National Sample of Transgender Men and Women

Abstract

ASJC Scopus Subject Areas

Keywords

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