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Reduced work capacity in individuals with down syndrome: A consequence of autonomic dysfunction?

  • University of Illinois at Chicago
  • University of Lisbon

Research output: Contribution to journal › Article › peer-review

Abstract

Low work capacity and VO2peak commonly are described phenomena in Down syndrome. This is accompanied by chronotropic incompetence and a high incidence of obesity. Although many causes of low work capacity in Down syndrome have been proposed, little scientific support exists. Our working hypothesis is that autonomic dysfunction is the major contributor to the low levels of work capacity in this population.

Original languageEnglish
Pages (from-to)138-147
Number of pages10
JournalExercise and Sport Sciences Reviews
Volume41
Issue number3
DOIs
StatePublished - Jul 2013

ASJC Scopus Subject Areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Keywords

  • catecholamine
  • heart rate variability
  • intellectual disability
  • sympathetic activation
  • vagal withdrawal
  • VO

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