Rheology of gastric mucin exhibits a pH-dependent sol-gel transition

Jonathan P. Celli; Bradley S. Turner; Nezam H. Afdhal; Randy H. Ewoldt; Gareth H. McKinley; Rama Bansil; Shyamsunder Erramilli

doi:10.1021/bm0609691

Rheology of gastric mucin exhibits a pH-dependent sol-gel transition

Jonathan P. Celli
, Bradley S. Turner
, Nezam H. Afdhal
, Randy H. Ewoldt
, Gareth H. McKinley
, Rama Bansil
, Shyamsunder Erramilli

Physics

Boston University
Harvard University
Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.

Original language	English
Pages (from-to)	1580-1586
Number of pages	7
Journal	Biomacromolecules
Volume	8
Issue number	5
DOIs	https://doi.org/10.1021/bm0609691
State	Published - May 2007

ASJC Scopus Subject Areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1021/bm0609691

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title = "Rheology of gastric mucin exhibits a pH-dependent sol-gel transition",

abstract = "Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.",

author = "Celli, \{Jonathan P.\} and Turner, \{Bradley S.\} and Afdhal, \{Nezam H.\} and Ewoldt, \{Randy H.\} and McKinley, \{Gareth H.\} and Rama Bansil and Shyamsunder Erramilli",

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AU - Celli, Jonathan P.

AU - Turner, Bradley S.

AU - Afdhal, Nezam H.

AU - Ewoldt, Randy H.

AU - McKinley, Gareth H.

AU - Bansil, Rama

AU - Erramilli, Shyamsunder

PY - 2007/5

Y1 - 2007/5

N2 - Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.

AB - Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.

UR - https://www.scopus.com/pages/publications/34249870086

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EP - 1586

JO - Biomacromolecules

JF - Biomacromolecules

IS - 5

ER -

Rheology of gastric mucin exhibits a pH-dependent sol-gel transition

Abstract

ASJC Scopus Subject Areas

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