Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

Bin Gui; Fu Gui; Tomoaki Takai; Chao Feng; Xiao Bai; Ladan Fazli; Xuesen Dong; Shuai Liu; Xiaofeng Zhang; Wei Zhang; Adam S. Kibel; Li Jia

doi:10.1073/pnas.1908547116

Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

Bin Gui
, Fu Gui
, Tomoaki Takai
, Chao Feng
, Xiao Bai
, Ladan Fazli
, Xuesen Dong
, Shuai Liu
, Xiaofeng Zhang
, Wei Zhang
, Adam S. Kibel
, Li Jia

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	14573-14582
Number of pages	10
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	116
Issue number	29
DOIs	https://doi.org/10.1073/pnas.1908547116
State	Published - 2019

ASJC Scopus Subject Areas

General

Keywords

Androgen receptor
FOXA1
PARP inhibitor
PARP-2
Prostate cancer

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10.1073/pnas.1908547116

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Gui, B., Gui, F., Takai, T., Feng, C., Bai, X., Fazli, L., Dong, X., Liu, S., Zhang, X., Zhang, W., Kibel, A. S., & Jia, L. (2019). Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function. Proceedings of the National Academy of Sciences of the United States of America, 116(29), 14573-14582. https://doi.org/10.1073/pnas.1908547116

Gui, B, Gui, F, Takai, T, Feng, C, Bai, X, Fazli, L, Dong, X, Liu, S, Zhang, X, Zhang, W, Kibel, AS & Jia, L 2019, 'Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 29, pp. 14573-14582. https://doi.org/10.1073/pnas.1908547116

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title = "Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function",

keywords = "Androgen receptor, FOXA1, PARP inhibitor, PARP-2, Prostate cancer",

author = "Bin Gui and Fu Gui and Tomoaki Takai and Chao Feng and Xiao Bai and Ladan Fazli and Xuesen Dong and Shuai Liu and Xiaofeng Zhang and Wei Zhang and Kibel, \{Adam S.\} and Li Jia",

year = "2019",

doi = "10.1073/pnas.1908547116",

language = "English",

volume = "116",

pages = "14573--14582",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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TY - JOUR

T1 - Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

AU - Gui, Bin

AU - Gui, Fu

AU - Takai, Tomoaki

AU - Feng, Chao

AU - Bai, Xiao

AU - Fazli, Ladan

AU - Dong, Xuesen

AU - Liu, Shuai

AU - Zhang, Xiaofeng

AU - Zhang, Wei

AU - Kibel, Adam S.

AU - Jia, Li

PY - 2019

Y1 - 2019

KW - Androgen receptor

KW - FOXA1

KW - PARP inhibitor

KW - PARP-2

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/85069051632

UR - https://www.scopus.com/pages/publications/85069051632#tab=citedBy

U2 - 10.1073/pnas.1908547116

DO - 10.1073/pnas.1908547116

M3 - Article

C2 - 31266892

AN - SCOPUS:85069051632

SN - 0027-8424

VL - 116

SP - 14573

EP - 14582

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 29

ER -

Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

ASJC Scopus Subject Areas

Keywords

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