Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation

Jamie Voyles; Douglas C. Woodhams; Veronica Saenz; Allison Q. Byrne; Rachel Perez; Gabriela Rios-Sotelo; Mason J. Ryan; Molly C. Bletz; Florence Ann Sobell; Shawna McLetchie; Laura Reinert; Erica Bree Rosenblum; Louise A. Rollins-Smith; Roberto Ibáñez; Julie M. Ray; Edgardo J. Griffith; Heidi Ross; Corinne L. Richards-Zawacki

doi:10.1126/science.aao4806

Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation

Jamie Voyles
, Douglas C. Woodhams
, Veronica Saenz
, Allison Q. Byrne
, Rachel Perez
, Gabriela Rios-Sotelo
, Mason J. Ryan
, Molly C. Bletz
, Florence Ann Sobell
, Shawna McLetchie
, Laura Reinert
, Erica Bree Rosenblum
, Louise A. Rollins-Smith
, Roberto Ibáñez
, Julie M. Ray
, Edgardo J. Griffith
, Heidi Ross
, Corinne L. Richards-Zawacki

Biology

University of Nevada, Reno
University of Pittsburgh
University of California at Berkeley
New Mexico Institute of Mining and Technology
Arizona Game and Fish Department
University of Massachusetts Boston
Vanderbilt University
Smithsonian Institution
Sistema Nacional de Investigación
La Mica Biological Station
Fundación Centro de Conservación de Anfibios

Research output: Contribution to journal › Article › peer-review

Abstract

Infectious diseases rarely end in extinction.Yet the mechanisms that explain how epidemics subside are difficult to pinpoint.We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as itwas almost a decade ago. In addition, some species have defenses that aremore effective now than they were before the epidemic.These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses. Our findings provide insights into the mechanisms underlying disease transitions, which are increasingly important to understand in an era of emerging infectious diseases and unprecedented global pandemics.

Original language	English
Pages (from-to)	1517-1519
Number of pages	3
Journal	Science
Volume	359
Issue number	6383
DOIs	https://doi.org/10.1126/science.aao4806
State	Published - Mar 30 2018

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Voyles, J., Woodhams, D. C., Saenz, V., Byrne, A. Q., Perez, R., Rios-Sotelo, G., Ryan, M. J., Bletz, M. C., Sobell, F. A., McLetchie, S., Reinert, L., Rosenblum, E. B., Rollins-Smith, L. A., Ibáñez, R., Ray, J. M., Griffith, E. J., Ross, H., & Richards-Zawacki, C. L. (2018). Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation. Science, 359(6383), 1517-1519. https://doi.org/10.1126/science.aao4806

Voyles, J, Woodhams, DC, Saenz, V, Byrne, AQ, Perez, R, Rios-Sotelo, G, Ryan, MJ, Bletz, MC, Sobell, FA, McLetchie, S, Reinert, L, Rosenblum, EB, Rollins-Smith, LA, Ibáñez, R, Ray, JM, Griffith, EJ, Ross, H & Richards-Zawacki, CL 2018, 'Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation', Science, vol. 359, no. 6383, pp. 1517-1519. https://doi.org/10.1126/science.aao4806

@article{879628ecc8f747c5add7198bb6d8fce9,

title = "Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation",

abstract = "Infectious diseases rarely end in extinction.Yet the mechanisms that explain how epidemics subside are difficult to pinpoint.We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as itwas almost a decade ago. In addition, some species have defenses that aremore effective now than they were before the epidemic.These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses. Our findings provide insights into the mechanisms underlying disease transitions, which are increasingly important to understand in an era of emerging infectious diseases and unprecedented global pandemics.",

author = "Jamie Voyles and Woodhams, \{Douglas C.\} and Veronica Saenz and Byrne, \{Allison Q.\} and Rachel Perez and Gabriela Rios-Sotelo and Ryan, \{Mason J.\} and Bletz, \{Molly C.\} and Sobell, \{Florence Ann\} and Shawna McLetchie and Laura Reinert and Rosenblum, \{Erica Bree\} and Rollins-Smith, \{Louise A.\} and Roberto Ib{\'a}{\~n}ez and Ray, \{Julie M.\} and Griffith, \{Edgardo J.\} and Heidi Ross and Richards-Zawacki, \{Corinne L.\}",

note = "Publisher Copyright: {\textcopyright} The Authors, some rights reserved;.",

year = "2018",

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doi = "10.1126/science.aao4806",

language = "English",

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T1 - Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation

AU - Voyles, Jamie

AU - Woodhams, Douglas C.

AU - Saenz, Veronica

AU - Byrne, Allison Q.

AU - Perez, Rachel

AU - Rios-Sotelo, Gabriela

AU - Ryan, Mason J.

AU - Bletz, Molly C.

AU - Sobell, Florence Ann

AU - McLetchie, Shawna

AU - Reinert, Laura

AU - Rosenblum, Erica Bree

AU - Rollins-Smith, Louise A.

AU - Ibáñez, Roberto

AU - Ray, Julie M.

AU - Griffith, Edgardo J.

AU - Ross, Heidi

AU - Richards-Zawacki, Corinne L.

PY - 2018/3/30

Y1 - 2018/3/30

N2 - Infectious diseases rarely end in extinction.Yet the mechanisms that explain how epidemics subside are difficult to pinpoint.We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as itwas almost a decade ago. In addition, some species have defenses that aremore effective now than they were before the epidemic.These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses. Our findings provide insights into the mechanisms underlying disease transitions, which are increasingly important to understand in an era of emerging infectious diseases and unprecedented global pandemics.

AB - Infectious diseases rarely end in extinction.Yet the mechanisms that explain how epidemics subside are difficult to pinpoint.We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as itwas almost a decade ago. In addition, some species have defenses that aremore effective now than they were before the epidemic.These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses. Our findings provide insights into the mechanisms underlying disease transitions, which are increasingly important to understand in an era of emerging infectious diseases and unprecedented global pandemics.

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JO - Science

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ER -

Shifts in disease dynamics in a tropical amphibian assemblage are not due to pathogen attenuation

Abstract

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