Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity

Nathan C. Charlton; Maxim Mastyugin; Béla Török; Marianna Török

doi:10.3390/molecules28031057

Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity

Nathan C. Charlton
, Maxim Mastyugin
, Béla Török
, Marianna Török

Chemistry

University of Massachusetts Boston

Research output: Contribution to journal › Review article › peer-review

Abstract

This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.

Original language	English
Article number	1057
Journal	Molecules
Volume	28
Issue number	3
DOIs	https://doi.org/10.3390/molecules28031057
State	Published - Feb 2023

ASJC Scopus Subject Areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

Keywords

anilines
antioxidant
hydrazones
isoprenoids
polyphenols
ROS/RNS
Schiff-bases
strategic modifications
thiols

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10.3390/molecules28031057

Cite this

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title = "Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity",

abstract = "This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.",

keywords = "anilines, antioxidant, hydrazones, isoprenoids, polyphenols, ROS/RNS, Schiff-bases, strategic modifications, thiols",

author = "Charlton, \{Nathan C.\} and Maxim Mastyugin and B{\'e}la T{\"o}r{\"o}k and Marianna T{\"o}r{\"o}k",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = feb,

doi = "10.3390/molecules28031057",

language = "English",

volume = "28",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity

AU - Charlton, Nathan C.

AU - Mastyugin, Maxim

AU - Török, Béla

AU - Török, Marianna

PY - 2023/2

Y1 - 2023/2

N2 - This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.

AB - This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.

KW - anilines

KW - antioxidant

KW - hydrazones

KW - isoprenoids

KW - polyphenols

KW - ROS/RNS

KW - Schiff-bases

KW - strategic modifications

KW - thiols

UR - https://www.scopus.com/pages/publications/85147894901

UR - https://www.scopus.com/pages/publications/85147894901#tab=citedBy

U2 - 10.3390/molecules28031057

DO - 10.3390/molecules28031057

M3 - Review article

C2 - 36770724

AN - SCOPUS:85147894901

SN - 1420-3049

VL - 28

JO - Molecules

JF - Molecules

IS - 3

M1 - 1057

ER -

Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity

Abstract

ASJC Scopus Subject Areas

Keywords

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