Abstract
A new superacid catalyzed Friedel-Crafts hydroxyalkylation of aromatics with ethyl trifluoropyruvate is described. The trifluoromethanesulfonic acid or gallium(III) trifluoromethane-sulfonate catalyzed reactions give α-hydroxy α-trifluoromethyl phenyl acetic acid ethyl ester and its derivatives (analogs of Mosher's acid) in good yields for both highly activated heteroaromatics and substituted benzenes.
| Original language | English |
|---|---|
| Pages (from-to) | 527-531 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 4 |
| DOIs | |
| State | Published - 2003 |
ASJC Scopus Subject Areas
- Organic Chemistry
Keywords
- Friedel-Crafts hydroxyalkylation
- Gallium triflate
- Mosher's acid
- Trifluoromethanesulfonic acid
- α-trifluoromethyl alcohol
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