Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase i and histone deacetylase 8

Monica Ilies; Daniel P. Dowling; Patrick M. Lombardi; David W. Christianson

doi:10.1016/j.bmcl.2011.07.100

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase i and histone deacetylase 8

Monica Ilies
, Daniel P. Dowling
, Patrick M. Lombardi
, David W. Christianson

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	5854-5858
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2011.07.100
State	Published - Oct 1 2011

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Keywords

Drug target
Enzyme inhibitor
Metalloenzyme

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10.1016/j.bmcl.2011.07.100

Cite this

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase i and histone deacetylase 8. / Ilies, Monica; Dowling, Daniel P.; Lombardi, Patrick M. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 19, 01.10.2011, p. 5854-5858.

Research output: Contribution to journal › Article › peer-review

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author = "Monica Ilies and Dowling, \{Daniel P.\} and Lombardi, \{Patrick M.\} and Christianson, \{David W.\}",

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AU - Ilies, Monica

AU - Dowling, Daniel P.

AU - Lombardi, Patrick M.

AU - Christianson, David W.

PY - 2011/10/1

Y1 - 2011/10/1

KW - Drug target

KW - Enzyme inhibitor

KW - Metalloenzyme

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DO - 10.1016/j.bmcl.2011.07.100

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AN - SCOPUS:80052586484

SN - 0960-894X

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SP - 5854

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase i and histone deacetylase 8

ASJC Scopus Subject Areas

Keywords

Access to Document

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