Abstract
Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind-Srogl reaction and Suzuki coupling to form biaryl-substituted dihydropyrimidinone, dihydropyrimidine, and thiazolopyrimidine compounds. The high efficiency of the diversity-oriented synthesis is achieved by conducting a multicomponent reaction for improved atom economy, under microwave heating for fast reaction, and with fluorous solid-phase extractions (F-SPE) for ease of purification.
| Original language | English |
|---|---|
| Article number | 150 |
| Pages (from-to) | 1294-1298 |
| Number of pages | 5 |
| Journal | Beilstein Journal of Organic Chemistry |
| Volume | 7 |
| DOIs | |
| State | Published - Sep 16 2011 |
ASJC Scopus Subject Areas
- Organic Chemistry
Keywords
- Biginelli reaction
- Dihydropyrimidine
- Diversity-oriented synthesis
- Fluorous
- Suzuki coupling
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