Synthesis of the Cancer-Associated KH-1 Antigen by Block Assembly of Its Backbone Structure Followed by One-Step Grafting of Three Fucose Residues

Qingjiang Li; Zhongwu Guo

doi:10.1021/acs.orglett.7b03275

Synthesis of the Cancer-Associated KH-1 Antigen by Block Assembly of Its Backbone Structure Followed by One-Step Grafting of Three Fucose Residues

Qingjiang Li
, Zhongwu Guo

Chemistry

University of Florida

Research output: Contribution to journal › Article › peer-review

Abstract

A robust, convergent, and efficient strategy was developed for the synthesis of the nonasaccharide cancer antigen KH-1. This strategy featured a one-pot block assembly of the linear hexasaccharide backbone using three disaccharides followed by grafting of three fucose residues onto the backbone in one step.

Original language	English
Pages (from-to)	6558-6561
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	24
DOIs	https://doi.org/10.1021/acs.orglett.7b03275
State	Published - Dec 15 2017

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.7b03275

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title = "Synthesis of the Cancer-Associated KH-1 Antigen by Block Assembly of Its Backbone Structure Followed by One-Step Grafting of Three Fucose Residues",

abstract = "A robust, convergent, and efficient strategy was developed for the synthesis of the nonasaccharide cancer antigen KH-1. This strategy featured a one-pot block assembly of the linear hexasaccharide backbone using three disaccharides followed by grafting of three fucose residues onto the backbone in one step.",

author = "Qingjiang Li and Zhongwu Guo",

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AB - A robust, convergent, and efficient strategy was developed for the synthesis of the nonasaccharide cancer antigen KH-1. This strategy featured a one-pot block assembly of the linear hexasaccharide backbone using three disaccharides followed by grafting of three fucose residues onto the backbone in one step.

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Synthesis of the Cancer-Associated KH-1 Antigen by Block Assembly of Its Backbone Structure Followed by One-Step Grafting of Three Fucose Residues

Abstract

ASJC Scopus Subject Areas

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