Synthetic applications of fluorous solid-phase extraction (F-SPE)

Wei Zhang; Dennis P. Curran

doi:10.1016/j.tet.2006.08.051

Synthetic applications of fluorous solid-phase extraction (F-SPE)

Wei Zhang
, Dennis P. Curran

Chemistry

University of Pittsburgh

Research output: Contribution to journal › Review article › peer-review

Abstract

The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.

Original language	English
Pages (from-to)	11837-11865
Number of pages	29
Journal	Tetrahedron
Volume	62
Issue number	51
DOIs	https://doi.org/10.1016/j.tet.2006.08.051
State	Published - Dec 18 2006

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Catalysts
Chiral auxiliaries
Displaceable tags
Ex-Block
FlashMaster™
FluoroFlash
Fluorous
Fluorous silica gel
Fluorous solid-phase extraction (F-SPE)
High-throughput synthesis
Light fluorous
Parallel synthesis
Plate-to-plate SPE
Protecting groups
RapidTrace
Reactants
Reagents
Reverse F-SPE
Scavengers
Separation
Solution-phase synthesis
VacMaster
Whatman

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10.1016/j.tet.2006.08.051

Cite this

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title = "Synthetic applications of fluorous solid-phase extraction (F-SPE)",

abstract = "The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 {\texttimes} 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.",

keywords = "Catalysts, Chiral auxiliaries, Displaceable tags, Ex-Block, FlashMaster{\texttrademark}, FluoroFlash, Fluorous, Fluorous silica gel, Fluorous solid-phase extraction (F-SPE), High-throughput synthesis, Light fluorous, Parallel synthesis, Plate-to-plate SPE, Protecting groups, RapidTrace, Reactants, Reagents, Reverse F-SPE, Scavengers, Separation, Solution-phase synthesis, VacMaster, Whatman",

author = "Wei Zhang and Curran, \{Dennis P.\}",

year = "2006",

month = dec,

day = "18",

doi = "10.1016/j.tet.2006.08.051",

language = "English",

volume = "62",

pages = "11837--11865",

journal = "Tetrahedron",

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T1 - Synthetic applications of fluorous solid-phase extraction (F-SPE)

AU - Zhang, Wei

AU - Curran, Dennis P.

PY - 2006/12/18

Y1 - 2006/12/18

N2 - The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.

AB - The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.

KW - Catalysts

KW - Chiral auxiliaries

KW - Displaceable tags

KW - Ex-Block

KW - FlashMaster™

KW - FluoroFlash

KW - Fluorous

KW - Fluorous silica gel

KW - Fluorous solid-phase extraction (F-SPE)

KW - High-throughput synthesis

KW - Light fluorous

KW - Parallel synthesis

KW - Plate-to-plate SPE

KW - Protecting groups

KW - RapidTrace

KW - Reactants

KW - Reagents

KW - Reverse F-SPE

KW - Scavengers

KW - Separation

KW - Solution-phase synthesis

KW - VacMaster

KW - Whatman

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UR - https://www.scopus.com/pages/publications/33750910189#tab=citedBy

U2 - 10.1016/j.tet.2006.08.051

DO - 10.1016/j.tet.2006.08.051

M3 - Review article

AN - SCOPUS:33750910189

SN - 0040-4020

VL - 62

SP - 11837

EP - 11865

JO - Tetrahedron

JF - Tetrahedron

IS - 51

ER -

Synthetic applications of fluorous solid-phase extraction (F-SPE)

Abstract

ASJC Scopus Subject Areas

Keywords

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