Testosterone regulates BCL-2 immunoreactivity in a sexually dimorphic motor pool of adult rats

Susan L. Zup; Nancy G. Forger

doi:10.1016/S0006-8993(02)03190-6

Testosterone regulates BCL-2 immunoreactivity in a sexually dimorphic motor pool of adult rats

Susan L. Zup
, Nancy G. Forger

Psychology

University of Massachusetts
University of Maryland, Baltimore

Research output: Contribution to journal › Article › peer-review

Abstract

Bcl-2 and Bax immunoreactivity were examined in the spinal nucleus of the bulbocavernosus (SNB), an androgen-sensitive motor pool of adult rats. Castration reduced Bcl-2 immunoreactivity and testosterone treatment of castrates prevented this decline. Hormone manipulations did not affect Bcl-2 or Bax staining in the retrodorsolateral nucleus (RDLN), a relatively androgen-insensitive nucleus at the same spinal level. Changes in Bcl-2 expression may underlie the hormonal control of cell death and/or neural plasticity in SNB motoneurons.

Original language	English
Pages (from-to)	312-316
Number of pages	5
Journal	Brain Research
Volume	950
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03190-6
State	Published - Sep 20 2002

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Androgen
Bax
Bcl-2
Cell death
Neural plasticity
Spinal nucleus of the bulbocavernosus

Access to Document

10.1016/S0006-8993(02)03190-6

Cite this

@article{f966f9d5f6b2424dba6883e75cb5d955,

title = "Testosterone regulates BCL-2 immunoreactivity in a sexually dimorphic motor pool of adult rats",

abstract = "Bcl-2 and Bax immunoreactivity were examined in the spinal nucleus of the bulbocavernosus (SNB), an androgen-sensitive motor pool of adult rats. Castration reduced Bcl-2 immunoreactivity and testosterone treatment of castrates prevented this decline. Hormone manipulations did not affect Bcl-2 or Bax staining in the retrodorsolateral nucleus (RDLN), a relatively androgen-insensitive nucleus at the same spinal level. Changes in Bcl-2 expression may underlie the hormonal control of cell death and/or neural plasticity in SNB motoneurons.",

keywords = "Androgen, Bax, Bcl-2, Cell death, Neural plasticity, Spinal nucleus of the bulbocavernosus",

author = "Zup, \{Susan L.\} and Forger, \{Nancy G.\}",

year = "2002",

month = sep,

day = "20",

doi = "10.1016/S0006-8993(02)03190-6",

language = "English",

volume = "950",

pages = "312--316",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Testosterone regulates BCL-2 immunoreactivity in a sexually dimorphic motor pool of adult rats

AU - Zup, Susan L.

AU - Forger, Nancy G.

PY - 2002/9/20

Y1 - 2002/9/20

N2 - Bcl-2 and Bax immunoreactivity were examined in the spinal nucleus of the bulbocavernosus (SNB), an androgen-sensitive motor pool of adult rats. Castration reduced Bcl-2 immunoreactivity and testosterone treatment of castrates prevented this decline. Hormone manipulations did not affect Bcl-2 or Bax staining in the retrodorsolateral nucleus (RDLN), a relatively androgen-insensitive nucleus at the same spinal level. Changes in Bcl-2 expression may underlie the hormonal control of cell death and/or neural plasticity in SNB motoneurons.

AB - Bcl-2 and Bax immunoreactivity were examined in the spinal nucleus of the bulbocavernosus (SNB), an androgen-sensitive motor pool of adult rats. Castration reduced Bcl-2 immunoreactivity and testosterone treatment of castrates prevented this decline. Hormone manipulations did not affect Bcl-2 or Bax staining in the retrodorsolateral nucleus (RDLN), a relatively androgen-insensitive nucleus at the same spinal level. Changes in Bcl-2 expression may underlie the hormonal control of cell death and/or neural plasticity in SNB motoneurons.

KW - Androgen

KW - Bax

KW - Bcl-2

KW - Cell death

KW - Neural plasticity

KW - Spinal nucleus of the bulbocavernosus

UR - https://www.scopus.com/pages/publications/0037144153

UR - https://www.scopus.com/pages/publications/0037144153#tab=citedBy

U2 - 10.1016/S0006-8993(02)03190-6

DO - 10.1016/S0006-8993(02)03190-6

M3 - Article

C2 - 12231259

AN - SCOPUS:0037144153

SN - 0006-8993

VL - 950

SP - 312

EP - 316

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Testosterone regulates BCL-2 immunoreactivity in a sexually dimorphic motor pool of adult rats

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this