The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

Sunil K. Joshi; Tamilla Nechiporuk; Daniel Bottomly; Paul D. Piehowski; Julie A. Reisz; Janét Pittsenbarger; Andy Kaempf; Sara J.C. Gosline; Yi Ting Wang; Joshua R. Hansen; Marina A. Gritsenko; Chelsea Hutchinson; Karl K. Weitz; Jamie Moon; Francesca Cendali; Thomas L. Fillmore; Chia Feng Tsai; Athena A. Schepmoes; Tujin Shi; Osama A. Arshad; Jason E. McDermott; Ozgun Babur; Kevin Watanabe-Smith; Emek Demir; Angelo D'Alessandro; Tao Liu; Cristina E. Tognon; Jeffrey W. Tyner; Shannon K. McWeeney; Karin D. Rodland; Brian J. Druker; Elie Traer

doi:10.1016/j.ccell.2021.06.003

The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

Sunil K. Joshi
, Tamilla Nechiporuk
, Daniel Bottomly
, Paul D. Piehowski
, Julie A. Reisz
, Janét Pittsenbarger
, Andy Kaempf
, Sara J.C. Gosline
, Yi Ting Wang
, Joshua R. Hansen
, Marina A. Gritsenko
, Chelsea Hutchinson
, Karl K. Weitz
, Jamie Moon
, Francesca Cendali
, Thomas L. Fillmore
, Chia Feng Tsai
, Athena A. Schepmoes
, Tujin Shi
, Osama A. Arshad

Jason E. McDermott, Ozgun Babur, Kevin Watanabe-Smith, Emek Demir, Angelo D'Alessandro, Tao Liu, Cristina E. Tognon, Jeffrey W. Tyner, Shannon K. McWeeney, Karin D. Rodland, Brian J. Druker, Elie Traer

Computer Science

Oregon Health and Science University
Pacific Northwest National Laboratory
University of Colorado Anschutz Medical Campus

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	999-1014.e8
Journal	Cancer Cell
Volume	39
Issue number	7
DOIs	https://doi.org/10.1016/j.ccell.2021.06.003
State	Published - Jul 12 2021

ASJC Scopus Subject Areas

Oncology
Cancer Research

Keywords

AML
Aurora kinase B
drug resistance
FLT3
gilteritinib
lipid metabolism
NRAS
quizartinib
tumor microenvironment
tyrosine kinase inhibitor

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10.1016/j.ccell.2021.06.003

Cite this

Joshi, S. K., Nechiporuk, T., Bottomly, D., Piehowski, P. D., Reisz, J. A., Pittsenbarger, J., Kaempf, A., Gosline, S. J. C., Wang, Y. T., Hansen, J. R., Gritsenko, M. A., Hutchinson, C., Weitz, K. K., Moon, J., Cendali, F., Fillmore, T. L., Tsai, C. F., Schepmoes, A. A., Shi, T., ... Traer, E. (2021). The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance. Cancer Cell, 39(7), 999-1014.e8. https://doi.org/10.1016/j.ccell.2021.06.003

Joshi, SK, Nechiporuk, T, Bottomly, D, Piehowski, PD, Reisz, JA, Pittsenbarger, J, Kaempf, A, Gosline, SJC, Wang, YT, Hansen, JR, Gritsenko, MA, Hutchinson, C, Weitz, KK, Moon, J, Cendali, F, Fillmore, TL, Tsai, CF, Schepmoes, AA, Shi, T, Arshad, OA, McDermott, JE, Babur, O, Watanabe-Smith, K, Demir, E, D'Alessandro, A, Liu, T, Tognon, CE, Tyner, JW, McWeeney, SK, Rodland, KD, Druker, BJ & Traer, E 2021, 'The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance', Cancer Cell, vol. 39, no. 7, pp. 999-1014.e8. https://doi.org/10.1016/j.ccell.2021.06.003

@article{58516623ba8d4bb891531bd298abb8ed,

title = "The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance",

keywords = "AML, Aurora kinase B, drug resistance, FLT3, gilteritinib, lipid metabolism, NRAS, quizartinib, tumor microenvironment, tyrosine kinase inhibitor",

author = "Joshi, \{Sunil K.\} and Tamilla Nechiporuk and Daniel Bottomly and Piehowski, \{Paul D.\} and Reisz, \{Julie A.\} and Jan{\'e}t Pittsenbarger and Andy Kaempf and Gosline, \{Sara J.C.\} and Wang, \{Yi Ting\} and Hansen, \{Joshua R.\} and Gritsenko, \{Marina A.\} and Chelsea Hutchinson and Weitz, \{Karl K.\} and Jamie Moon and Francesca Cendali and Fillmore, \{Thomas L.\} and Tsai, \{Chia Feng\} and Schepmoes, \{Athena A.\} and Tujin Shi and Arshad, \{Osama A.\} and McDermott, \{Jason E.\} and Ozgun Babur and Kevin Watanabe-Smith and Emek Demir and Angelo D'Alessandro and Tao Liu and Tognon, \{Cristina E.\} and Tyner, \{Jeffrey W.\} and McWeeney, \{Shannon K.\} and Rodland, \{Karin D.\} and Druker, \{Brian J.\} and Elie Traer",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = jul,

day = "12",

doi = "10.1016/j.ccell.2021.06.003",

language = "English",

volume = "39",

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T1 - The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

AU - Joshi, Sunil K.

AU - Nechiporuk, Tamilla

AU - Bottomly, Daniel

AU - Piehowski, Paul D.

AU - Reisz, Julie A.

AU - Pittsenbarger, Janét

AU - Kaempf, Andy

AU - Gosline, Sara J.C.

AU - Wang, Yi Ting

AU - Hansen, Joshua R.

AU - Gritsenko, Marina A.

AU - Hutchinson, Chelsea

AU - Weitz, Karl K.

AU - Moon, Jamie

AU - Cendali, Francesca

AU - Fillmore, Thomas L.

AU - Tsai, Chia Feng

AU - Schepmoes, Athena A.

AU - Shi, Tujin

AU - Arshad, Osama A.

AU - McDermott, Jason E.

AU - Babur, Ozgun

AU - Watanabe-Smith, Kevin

AU - Demir, Emek

AU - D'Alessandro, Angelo

AU - Liu, Tao

AU - Tognon, Cristina E.

AU - Tyner, Jeffrey W.

AU - McWeeney, Shannon K.

AU - Rodland, Karin D.

AU - Druker, Brian J.

AU - Traer, Elie

PY - 2021/7/12

Y1 - 2021/7/12

KW - AML

KW - Aurora kinase B

KW - drug resistance

KW - FLT3

KW - gilteritinib

KW - lipid metabolism

KW - NRAS

KW - quizartinib

KW - tumor microenvironment

KW - tyrosine kinase inhibitor

UR - https://www.scopus.com/pages/publications/85111786579

UR - https://www.scopus.com/pages/publications/85111786579#tab=citedBy

U2 - 10.1016/j.ccell.2021.06.003

DO - 10.1016/j.ccell.2021.06.003

M3 - Article

C2 - 34171263

AN - SCOPUS:85111786579

SN - 1535-6108

VL - 39

SP - 999-1014.e8

JO - Cancer Cell

JF - Cancer Cell

IS - 7

ER -

The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

ASJC Scopus Subject Areas

Keywords

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