Abstract
The electron-withdrawing trifluoromethylthio group (CF3S) could significantly alter the parent molecules’ lipophilicity and other chemical and biological properties. Development of synthetic methods for the introduction of CF3S group is an active topic in organic and medicinal chemistry. Presented in this chapter are newly developed synthetic methods and associated reagents for direct trifluoromethylthiolation of aromatic and heterocyclic compounds. Challenges for trifluoromethylthiolation are also discussed.
| Original language | English |
|---|---|
| Title of host publication | Emerging Fluorinated Motifs Synthesis, Properties, and Applications |
| Subtitle of host publication | Volume 1: Volume 2 |
| Publisher | Wiley |
| Pages | 343-371 |
| Number of pages | 29 |
| Volume | 1-2 |
| ISBN (Electronic) | 9783527824342 |
| ISBN (Print) | 9783527824335 |
| DOIs | |
| State | Published - Jan 1 2020 |
ASJC Scopus Subject Areas
- General Chemistry
Keywords
- Aromatic
- Electrophilic
- Nucleophilic
- Radical
- Trifluoromethylthiolation
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